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Juhyun Lee

Name

[Lee, Juhyun]
  • Assistant Professor, Department of Bioengineering
  • Assistant Professor

Professional Preparation

    • 2010 B.S. in Biomedical EngineeringUniversity of Utah
    • 2012 M.S. in Biomedical EngineeringUniversity of Southern California (USC)
    • 2016 Ph.D. in BioengineeringUniversity of California Los Angeles (UCLA)

Appointments

    • June 2017 to Present Assistant Professor
      University of Texas at Arligton
    • Jan 2017 to July 2017 Postdoctoral Scholar
      UCLA Medical School

Memberships

  • Member
    • 2016 to Present American Association of Anatomists (AAA)
    • 2014 to Present American Heart Association (AHA)
    • 2012 to Present Biomedical Engineering Society (BMES)

Awards and Honors

    • Dec  2016 Travel Award sponsored by American Association of Anatomists (AAA)
    • Dec  2016 Notable Korean Scientist sponsored by Biological Research Information Center (BRIC)
    • Dec  2016 Harry M. Showman Prize sponsored by University of California Los Angeles (UCLA)
    • Dec  2015 Outstanding Paper Award sponsored by 18th International Conference on Transducer
    • Dec  2014 Reviewer Choice Award sponsored by Biomedical Engineering Society (BMES)
    • Dec  2013 Travel Award sponsored by Biomedical Engineering Society (BMES)
    • Dec  2012 4th Place sponsored by California Institute of Technology (Caltech)
    • Dec  2010 Undergraduate Research Scholar Designation (URSD) sponsored by University of Utah

Research and Expertise

  • Juhyun Lee

    Our research focuses on mechanotransduction of cardiac morphogenesis by integrating advanced imaging with zebrafish genetics with physiological significance to congenital heart diseases. We have been studying hemodynamic forces underlying the initiation of cardiac trabeculation. We have developed the in-house cardiac light-sheet fluorescent microscopy (LSFM) to capture the 3-D in vivo zebrafish heart for 4-D (3-D + time) computational fluid dynamics. By genetically manipulating the developmental blood viscosity and consequently fluid shear stress, we revealed the role of shear stress underlying the initiation of endocardial trabeculation via endothelial Notch-Nrg1-ErbB2 signaling pathway. In this context, we will further assess how biomechanical forces modulate ventricular development using computational super-resolution techniques to accurately characterize biomechanical forces. These findings will provide a basis to translate to the higher vertebral animal models. Our study will pave the way to understand pathophysiological significance of congenital heart disease such as left-ventricular non-compaction cardiomyopathy or hypoplastic heart syndrome.

Publications

      Journal Article Under Review
      • Vedula V, Lee J, Xu H, Kuo CCJ, Hsiai TK, and Marsden, AL, A framework for computing ventricular hemodynamics and wall shear stress in embryonic zebrafish

        {Journal Article }
      Under Review
      • Fei P*, Lee J*, Yu Z, Li S, Sereti K, Hagiwara M, Chen H, Kulkarni R, Huang Y, Ardehali R, Segura T, Ho CM, Hsiai TK, Oblique scaning light sheet microscopy microscopy for rapid voxel super-resolved, multi-dementional imaging of large organism *Co-first Authors

        {Journal Article }
      In-progress
      • Lee J, Vedula V, Ding YC, Ho CM, Marsden AL, Hsiai TK, Hemodynamic implications of ventricular trabecularion during cardiac morphogenesis 

        {Journal Article }

      Journal Article 2017
      • Lee J, Chou TC, Kang D, Chen J, Wang W, Di Carlo D, Tai YC, Hsiai TK, A Rapid Capillary-Pressure Driven Micro-Channel to Demonstrate Newtonian Fluid Behavior of Zebrafish Blood at High Shear Rates, Scientific Reports. 2017;7.

        {Journal Article }
      2017
      • Lee J*, Ding Y*, Ma J, Sung K, Yokota T, Singh N, Nakano A, Wang Y, Nguyen TP, Kulkarni R, Fei P, Hsiai TK, Light-sheet fluorescent imaging to localize cardiac lineage and protein distribution, Scientific Reports. 2017;7. *Co-first Authors

        {Journal Article }

      Journal Article 2016
      • Lee J, Fei P, Jen N, Kang H, Packard RRS, Ho CH, Li R, Hsiai TK. Light-Sheet Microscopy to Elucidate Hemodynamic Forces and Modulation of Cardiac Trabeculation: Implications for Embryonic Contractile Function. Journal of Clinical Investigation. 2016 Mar 28;126 (5)

        {Journal Article }
      2016
      • Lee J*, Guan Z*, Jiang H, Dong S, Jen N, Hsiai T, Ho CM, Fei P. Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope. Biomedical Optics Express. 2016 Jan 1;7(1):194-208. *Co-first Authors

        {Journal Article }

      Conference Paper 2016
      • Lee J*, Fei P*, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CCJ Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Scientific Reports. 2016;6. *Co-first Authors

        {Conference Paper }

      Journal Article 2015
      • Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics. Current opinion in lipidology. 2015 Oct 1;26(5):376-83.

        {Journal Article }
      2015
      • Li R, Jen N, Wu L, Lee J, Fang K, Quigley K, Lee K, Wang S, Zhou B, Vergnes L, Chen YR, Hsiai TK. Disturbed Flow Induces Autophagy But Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis. Antioxidants and Redox Signaling. 2015 May 28(ja). (Journal Cover Page)

        {Journal Article }

      Journal Article 2014
      • Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK. Shear Stress–Activated Wnt-Angiopoietin-2 Signaling Recapitulates Vascular Repair in Zebrafish Embryos. Arteriosclerosis, thrombosis, and vascular biology. 2014 Oct 1;34(10):2268-75. 

        {Journal Article }
      2014
      • Cao H, Yu F, Zhao Y, Zhang X, Tai J, Lee J, Darehzereshki A, Bersohn M, Lien CL, Chi NC, Tai YC, Hsiai TK. Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium. Integrative Biology. 2014;6(8):789-95. 

        {Journal Article }
      2014
      • Lee J, Cao H, Kang BJ, Jen N, Yu F, Lee CA, Fei P, Park J, Bohlool S, Lash-Rosenberg L, Shung KK, Hsiai TK. Hemodynamics and Ventricular Function in a Zebrafish Model of Injury and Repair. Zebrafish. 2014 Oct 1;11(5):447-54.

        {Journal Article }
      2014
      • Cao H, Yu F, Zhao Y, Scianmarello N, Lee J, Dai W, Jen N, Beebe T, Li R, Ebrahimi R, Chang DS, Mody FV, Pacella J, Tai TC, Hsiai T. Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits. Biosensors and Bioelectronics. 2014 Apr 15;54:610-6.

        {Journal Article }

      Journal Article 2013
      • Lee J, Moghadam ME, Kung E, Cao H, Beebe T, Miller Y, Roman BL, Lien CL, Chi NC, Marsden AL, Hsiai TK. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis. PloS one. 2013 Aug 1;8(8):e72924.

        {Journal Article }
      2013
      • Yu F, Lee J, Jen N, Li X, Zhang Q, Tang R, Zhou Q, Kim ES, Hsiai TK. Elevated electrochemical impedance in the endoluminal regions with high shear stress: Implication for assessing lipid-rich atherosclerotic lesions. Biosensors and Bioelectronics. 2013 May 15;43:237-44.

        {Journal Article }
      2013
      • Jen N, Yu F, Lee J, Wasmund S, Dai X, Chen C, Chawareeyawong P, Yang Y, Li R, Hamdan MH, Hsiai TK. Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function. Biomechanics and modeling in mechanobiology. 2013 Aug 1;12(4):735-45.

        {Journal Article }

      Journal Article 2012
      • Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. A dynamic model of calcific nodule destabilization in response to monocyte-and oxidized lipid-induced matrix metalloproteinases. American Journal of Physiology-Cell Physiology. 2012 Feb 15;302(4):C658-65. 

        {Journal Article }

Support & Funding

This data is entered manually by the author of the profile and may duplicate data in the Sponsored Projects section.
    • June 2017 to Present Hemodynamic implications of ventricular trabeculation during cardiac morphogenesis sponsored by  - $400000
    • Jan 2014 to Dec 2016 Integrating time-dependent 3-D Optical Techniques with Hemodynamics to Elucidate Cardiac Trabeculation sponsored by  - $50000

Courses

      • BE 3310-020 BIOMECHANICS AND FLUID FLOW WITH COMPUTATIONAL LAB

        Following an introduction to the basics of solid, fluid mechanics, student learn the fundamental behavior of various biological materials, flow properties of blood, viscoelastic properties of cells, tissue matrix, as well as their roles in human physiology at normal and disease states. Examples also include the design aspects of medical prosthetic devices. The course will cover biomechanics across a wide range of scales from organism, organ, tissue, cell and to protein levels. Students learn computational modeling to formulate and solve bioengineering problems

        Spring - Regular Academic Session - 2018 Download Syllabus Contact info & Office Hours
      • BE 5310-002 BIOMECHANICS AND FLUID FLOW WITH COMPUTATIONAL LAB

        Following an introduction to the basics of solid, fluid mechanics, student learn the fundamental behavior of various biological materials, flow properties of blood, viscoelastic properties of cells, tissue matrix, as well as their roles in human physiology at normal and disease states. Examples also include the design aspects of medical prosthetic devices. The course will cover biomechanics across a wide range of scales from organism, organ, tissue, cell and to protein levels. Students learn computational modeling to formulate and solve bioengineering problems

        Spring - Regular Academic Session - 2018 Download Syllabus Contact info & Office Hours