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Professional Preparation

    • 2005 PhD in Molecular MicrobiologyUniversity of Leeds, UK
    • 2000 Unknown degree in ChemistryUniversity of West Indies, Barbados

Appointments

    • Jan 2010 to Jan 2013 Assist Professor
      The University of Texas Arlington
    • Jan 2009 to Jan 2010 Research Specialist
      St Jude Children’s Research Hospital
    • Jan 2006 to Jan 2009 Postdoctoral Fellow
      University of Tennessee Health Sci. Center
    • Jan 2005 to Jan 2006 Research Asocciate
      University of Leeds, U.K.
    • July 1999 to Sept 2001 QA/QC Microbiologist
      Lentec Inc, Barbados

Research and Expertise

  • Molecular Mechanisms of Action and Characterization of Novel Antimicrobial Agents

    Antibiotics are essential in the treatment of bacterial infectious diseases, yet their utility is continually being diminished by the emergence of antibiotic-resistant organisms.My research explores the molecular action of antimicrobial agents against pathogenic bacteria; through inter-disciplinary collaboration we progress the discovery and development of novel agents that have a potential to treat serious infections.

Publications

      Book Chapter 2013
      • Wu X and Hurdle J.G. (2013). The Membrane as a Novel Target Site for Antibiotics to KillPersisting Bacterial Pathogens. In Gualerzi, Antibiotics - Targets, Mechanisms and Resistance (185-206). Wiley (In Press).
        {Book Chapter} [Refereed/Juried]

      Journal Article 2013
      • Shen L, M Maddox M, Adhikari S, Bruhn DF, Kumar M, Lee RE, Hurdle JG, Lee RE, Sun D. Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents. J Antibiot (Tokyo). 2013 Jun;66(6):319-25
        {Journal Article} [Refereed/Juried]
      2013
      • Wu X, Cherian PT, Lee RE, Hurdle JG. The membrane as a target for controlling hypervirulent Clostridium difficile infections. J Antimicrob Chemother. 2013 Apr;68(4):806-15.
        {Journal Article} [Refereed/Juried]

      Journal Article 2011
      • Hurdle, J.G., Heathcott, A.E., Yang, L., Yan. B., Lee, R.E. (2011) Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations. J Antimicrob Chemother; 66:1773-6.
        {Journal Article} [Refereed/Juried]
      2011
      • Hurdle, J.G., O’Neill, A.J., Chopra I. and Lee, R.E. (2011) Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.  Nat. Rev. Microbiol;9:62-75.
        {Journal Article} [Non-refereed/non-juried]
      2011
      • Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Korduláková J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE. The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem. 2011 (In Press Jul 24 PMID:21840723)
        {Journal Article} [Refereed/Juried]

      Journal Article 2010
      • Hevener, K., Yun, M.K., Qi, J., Kerr, I., Babaoglu, K., Hurdle, J., Balakrishna, K., White, S. and Lee, R.  (2010) Structural studies of pterin-based inhibitors of dihydropteroate synthase. J. Med. Chem.;53:166-77.
        {Journal Article} [Refereed/Juried]

      Journal Article 2009
      • Budha, N.R., Lee, R., Hurdle, J.G., Lee, R.E. and Meibohm, B. (2009) Simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacterium tuberculosis. Tuberculosis (Edinb); 89:378-85.
        {Journal Article} [Non-refereed/non-juried]
      2009
      • Sun, D., Scherman, M. S., Jones, V., Hurdle, J.G., Lenaerts, A. J., McNeill, M. R. and Lee, R.E. Discovery, synthesis and biological evaluation of piperidinol analogs with anti-tuberculosis activity. Bioorg. Med. Chem. 17:3588-3599
        {Journal Article} [Refereed/Juried]
      2009
      • Hurdle, J.G., Yendapally, R., Sun D and Lee, R.E. (2009)   Evaluation of analogs of reutericyclin as prospective candidates for staphylococcal skin infections. Antimicrob. Agents Chemother. 53:4028-31.
        {Journal Article} [Refereed/Juried]

      Journal Article 2008
      • Hurdle JG, Lee RB, Budha NR, Carson EI, Qi J, Scherman MS, Cho SH, McNeil MR, Lenaerts AJ, Franzblau SG, Meibohm B, Lee R. A microbiological assessment of novel nitrofuranylamides as antituberculosis agents J. Antimicrob. Chemother. 62:1037-45
        {Journal Article} [Refereed/Juried]
      2008
      • Yendapally, R, Hurdle, J.G, Carson, E. and Lee, R. (2008).  N-Substituted 3-Acetyltetramic acid derivatives as antibacterial agents. J. Med. Chem. 51:1487-91.
        {Journal Article} [Non-refereed/non-juried]
      2008
      • Grimes, K. D., Lu, Y., Zhang, Y., Luna, V. A., Hurdle, J. G., Carson, E. I., Qi, J., Kudrimoti, S., Rock, C. O., and Lee, R.E. (2008) Novel acylphosphate mimetics that target PlsY, an essential acyltransferase in Gram-positive bacteria. Chem. Med. Chem. 3:1936-1945.
        {Journal Article} [Refereed/Juried]

      Journal Article 2005
      • Hurdle, J.G., O’Neill, A.J., Mody, L., Bradley, S.F. and Chopra, I.  (2005). In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis. J. Antimicrob. Chemother.  56, 1166-8.
        {Journal Article} [Refereed/Juried]
      2005
      • Hurdle, J.G., O’Neill, A.J., and Chopra, I (2005). Prospects for aminoacyl-tRNA synthetase inhibitors as new antibacterial agents. Antimicrob. Agents and Chemother.  49, 4821-33.
        {Journal Article} [Refereed/Juried]

      Journal Article 2004
      • Hurdle, J.G., O’Neill, A.J. and Chopra, I. (2004). The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden. J. Antimicrob. Chemother. 53, 102-4.
        {Journal Article} [Refereed/Juried]
      2004
      • Hurdle, J.G., O’Neill, A.J. and Chopra, I. (2004). Anti-staphylococcal activity of indolmycin a potential topical agent for control of staphylococcal infections. J. Antimicrob. Chemother.  53, 549-52.
        {Journal Article} [Non-refereed/non-juried]
      2004
      • Hurdle, J.G., O’Neill, A.J., Ingham, E., Fishwick, C. and Chopra, I. (2004).  Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modelling techniques.  Antimicrobial Agents and Chemotherapy 48, 4366- 76.
        {Journal Article} [Non-refereed/non-juried]

Support & Funding

This data is entered manually by the author of the profile and may duplicate data in the Sponsored Projects section.
    • Jan 2011 to Jan 2016 Nature inspired treatments for persistent C. difficile infections sponsored by  - $1900000

Courses

      • BIOL 4317-001 BACTERIAL PATHOGENESIS
        This course provides fundamental and recent information on the mechanism of pathogenesis used by major bacterial pathogens, with a look at the genetic, molecular and biochemical strategies adopted by bacteria to avoid being killed by host immune system and antimicrobials, to cause disease or survive.
        Fall - Regular Academic Session - 2013 Download Syllabus
      • BIOL 5317-001 BACTERIAL PATHOGENESIS
        This course provides fundamental and recent information on the mechanism of pathogenesis used by major bacterial pathogens, with a look at the genetic, molecular and biochemical strategies adopted by bacteria to avoid being killed by host immune system and antimicrobials, to cause disease or survive.
        Fall - Regular Academic Session - 2013 Download Syllabus
      • BIOL 5440-001 Laboratory Methods in Bacterial Pathogenesis
        This course is intended enable students in ‘research-oriented’ studies in bacterial pathogenesis and medical microbiology.It provides students with a practical understanding of immunological, microbiological and molecular techniques to identify pathogens, detect virulence, and mechanisms of antibiotic resistance genes.
        Spring - Regular Academic Session - 2013 Download Syllabus
      • BIOL 4440-001 Laboratory Methods in Bacterial Pathogenesis
        This course is intended enable students in ‘research-oriented’ studies in bacterial pathogenesis and medical microbiology.It provides students with a practical understanding of immunological, microbiological and molecular techniques to identify pathogens, detect virulence, and mechanisms of antibiotic resistance genes.
        Spring - Regular Academic Session - 2013 Download Syllabus
      • BIOL 5317-001 BACTERIAL PATHOGENESIS
         This course provides fundamental and recent information on the mechanism of pathogenesis used by major bacterial pathogens, with a look at the genetic, molecular and biochemical strategies adopted by bacteria to avoid being killed by host immune system and antimicrobials, to cause disease or survive.
        Fall - Regular Academic Session - 2012 Download Syllabus
      • BIOL 4317-001 BACTERIAL PATHOGENESIS
        This course provides fundamental and recent information on the mechanism of pathogenesis used by major bacterial pathogens, with a look at the genetic, molecular and biochemical strategies adopted by bacteria to avoid being killed by host immune system and antimicrobials, to cause disease or survive.
        Fall - Regular Academic Session - 2012 Download Syllabus
      • BIOL 5310-001 Bioinformatics
        A research course for Graduate students to evaluate and develop laboratory methods for a future undergraduate course on laboratory skills in bacterial pathogenesis.  Students will be required to research and test methods that are suitable for an undergraduate class format.This course will use molecular and classical techniques for the isolation, identification, and characterization of pathogenic bacteria and analysis of bacterial response to stimuli.  Techniques may include PCR, Gene Sequencing, SDS-PAGE and serotyping.
        Spring - Regular Academic Session - 2012 Download Syllabus
      • BIOL 3444-002 General Microbiology
        This course is designed to provide you with the basic information about a microbial cell. At the end of the course, you must be able to understand and describe: structural differences between Gram-positive, Gram-negative and Archaeal bacteria; the growth phases of a microbe, describing events at each phase; metabolic pathways used to generate energy in prokaryotes; microbial transcription, translation and replication; effects of mutations on microbial growth, evolution and microbial diversity; how microbes cause diseases and response of host defense; epidemiology of infectious diseases; beneficial role of microbes on earth and human society. It is anticipated that you should appreciate the diversity of microbial systems and ecological interactions with eukaryotes.
        Fall - Regular Academic Session - 2011 Download Syllabus
      • BIOL 3444-002 General Microbiology
        This course is designed to provide you with the basic information about a microbial cell. At the end of the course, you must be able to understand and describe: structural differences between Gram-positive, Gram-negative and Archaeal bacteria; the growth phases of a microbe, describing events at each phase; metabolic pathways used to generate energy in prokaryotes; microbial transcription, translation and replication; effects of mutations on microbial growth, evolution and microbial diversity; how microbes cause diseases and response of host defense; epidemiology of infectious diseases; beneficial role of microbes on earth and human society. It is anticipated that you should appreciate the diversity of microbial systems and ecological interactions with eukaryotes.
        Fall - Regular Academic Session - 2011 Download Syllabus
      • BIOL 3444-002 General Microbiology
        This course is designed to provide you with the basic information about a microbial cell. At the end of the course, you must be able to understand and describe: structural differences between Gram-positive, Gram-negative and Archaeal bacteria; the growth phases of a microbe, describing events at each phase; metabolic pathways used to generate energy in prokaryotes; microbial transcription, translation and replication; effects of mutations on microbial growth, evolution and microbial diversity; how microbes cause diseases and response of host defense; epidemiology of infectious diseases; beneficial role of microbes on earth and human society. It is anticipated that you should appreciate the diversity of microbial systems and ecological interactions with eukaryotes.
        Fall - Regular Academic Session - 2011 Download Syllabus
      • BIOL 3444-002 General Microbiology
        This course is designed to provide you with the basic information about a microbial cell. At the end of the course, you must be able to understand and describe: structural differences between Gram-positive, Gram-negative and Archaeal bacteria; the growth phases of a microbe, describing events at each phase; metabolic pathways used to generate energy in prokaryotes; microbial transcription, translation and replication; effects of mutations on microbial growth, evolution and microbial diversity; how microbes cause diseases and response of host defense; epidemiology of infectious diseases; beneficial role of microbes on earth and human society. It is anticipated that you should appreciate the diversity of microbial systems and ecological interactions with eukaryotes.
        Fall - Regular Academic Session - 2011 Download Syllabus