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Jun Liao

Name

[Liao, Jun]
  • Associate Professor, Department of Bioengineering

Biography

Dr. Jun Liao received his Ph.D. in biomedical engineering from the Cleveland Clinic Foundation/Cleveland State University. After his postdoctoral training at the University of Pittsburgh, Dr. Liao has focused his research on tissue biomechanics and bioengineering, which cover cardiac tissue bioengineering, heart valve biomechanics, soft tissue biomechanics, and human body simulations. Dr. Liao’s research interest is to better understand the role of biomechanics in maintaining optimal tissue performance in physiological conditions and the biomechanical abnormality in diseased/injury conditions. The hope is to apply the gained knowledge to better design tissue replacements, medical interventions, and safety countermeasures. Dr. Liao has published 70 peer-reviewed journal articles, 140 conference abstracts, and 6 book chapters in tissue biomechanics and bioengineering field. His research has been funded by NIH, AHA, DoD, DOE, NSF, and NASA. Dr. Liao was elected as a Fellow of American Heart Association in 2014.

Link to Tissue Biomechanics & Bioengineering Laboratory: http://omega.uta.edu/~liaoj

Professional Preparation

    • 2003 Ph.D. in Biomedical EngineeringCleveland Clinic Foundation/Cleveland State University
    • 1996 M.S. in Material Science & EngineeringSichuan University
    • 1993 B.S. in PhysicsSichuan University
    • 2005 Postdoctoral Fellow in BioengineeringUniversity of Pittsburgh

Appointments

    • Jan 2017 to Present Associate Professor, Tenured
      University of Texas at Arlington   The University of Texas at Arlington
    • Aug 2013 to Dec 2016 Associate Professor, Tenured
      Mississippi State University
    • Jan 2007 to July 2013 Assistant Professor
      Mississippi State University
    • Jan 2006 to Dec 2006 Research Assistant Professor
      University of Pittsburgh
    • Jan 2004 to Dec 2005 Postdoctoral Reserach Fellow
      University of Pittsburgh

Memberships

  • Member
    • 2017 to Present AAAS - American Association for the Advancement of Science
    • 2007 to Present American Society of Mechanical Engineering (ASME)
    • 2007 to Present Society for Biomaterials (SFB)
    • 2004 to Present Biomedical Engineering Society (BMES)
  • Fellow
    • 2005 to Present American Heart Association (AHA)

Awards and Honors

    • Jan  2011 Innovation Excellence sponsored by Mississippi State University
    • Dec  2010 The Shackouls Honors Faculty Medallion sponsored by Mississippi State University
    • Dec  2010 The State Pride Award sponsored by Mississippi State University
    • Dec  2002 Lerner Research Institute Graduate Award sponsored by The Cleveland Clinic Foundation

Research and Expertise

  • Tissue Biomechanics and Bioengineering

    Tissue Biomechanics, Tissue Engineering and Regeneration, Cardiac Biomechanics and Regeneration, Heart Valve Biomechanics and Bioengineering, Human Body Simulations

Publications

      Book Chapter Published
      • 1.       Bryn Brazile, Sallie Lin, Katherine M. Copeland, J. Ryan Butler, Jianjun Guan, and Jun Liao. Ultrastructure and Biomechanical Properties of the Skeletal Muscle ECM: Implications in Tissue Regeneration. Skeletal Muscle Regeneration. Editor: Justin Brown, Elsevier (In press, 2016)

        2.      Sourav S. Patnaik, Ali Borazjani, Bryn Brazile, Benjamin Weed, David Christiansen, Peter L. Ryan, C.H. van der Vaart, Margot Damaser, Jun Liao. Chapter 6: "Pelvic Floor Biomechanics from Animal Models" in Biomechanics of the Female Pelvic Floor, Editors: Lennox Hoyte and Margot Damaser, Elsevier, Pages 131–148, 2016

        3.      Bo Wang, Lakiesha Williams, Amy L. de Jongh Curry, Jun Liao. Chapter Title: “Preparation of Acellular Myocardial Scaffolds with Well-preserved Cardiomyocyte Lacunae, and Method for Applying Mechanical and Electrical Simulation to Tissue Construct.” Book Title: Cardiac Tissue Engineering Methods and Protocols. Editors: Milica Radisic and Lauren Black; Springer Science. 1181:189-202, 2014

        4.      Sourav S. Patnaik, Bo Wang, Benjamin Weed, Jason A. Wertheim, Jun Liao, Chapter 3: “Decellularized Scaffolds: Concepts, Methodologies, and Applications in Cardiac Tissue Engineering and Whole-Organ Regeneration,” Tissue Regeneration: Where Nanostructure Meets Biology, Editor: Qing Liu; World Scientific Company, page 77-124, 2013

        5.      Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao. Chapter Title: “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering. Book Title: “Advances in Engineering for Surgery – from information-guided surgery to cell-based medicine.” Editor: Ming Chyu; Multi-Science Publishing Company; Page 25-248, 2013

        6.      John A. Stella, Jun Liao, Yi Hong, W. David Merryman, William R. Wagner, and Michael S. Sacks. "Tissue-to-cellular deformation coupling in cell microintegrated elastomeric scaffolds." IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, IUTAM Bookseries: Volume 16 (Part 2) 81-89, Springer Netherlands, 2010.

        {Book Chapter }

      Journal Article Published
      • 2016

        1.       Christopher Deborde, Dan T. Simionescu, Cristopher Wright, Jun Liao, Leslie N. Sierad, Agneta Simionescu. Stabilized collagen and elastin-based scaffolds for mitral valve tissue engineering. Tissue Engineering Part A. 22(21-22):1241-1251, 2016

        2.      Kovach AK, Gambino JM, Nguyen V, Nelson Z, Szasz T, Liao J, Williams L, Bulla S, Prabhu R. Prospective Preliminary In Vitro Investigation of a Magnetic Iron Oxide Nanoparticle Conjugated with Ligand CD80 and VEGF Antibody As a Targeted Drug Delivery System for the Induction of Cell Death in Rodent Osteosarcoma Cells. Bioresearch Open Access. 5(1):299-307, 2016

        3.      Nayeon Lee, Mark F. Horstemeyer, Raj Prabhu, Jun Liao, Hongjoo Rhee, Youssef Hammi, Robert Moser, Lakiesha Williams, The geometric effects of a woodpeckers hyoid apparatus for stress wave mitigation. Bioinspiration & Biomimetics, 11(6) 066004, 2016

        4.      Mazin S Sirry, J Ryan Butler, Sourav S Patnaik, Bryn Brazile, Robbin Bertucci, Andrew Claude, Ron McLaughlin, Neil H Davies, Jun Liao, Thomas Franz. Characterization of the mechanical properties of infarcted myocardium in the rat under biaxial tension and uniaxial compression. Journal of the Mechanical Behavior of Biomedical Materials. 63: 252-264, 2016

        5.      Bo Wang, Sourav S. Patnaik, Bryn Brazile, J. Ryan Butler, Andrew Claude, Ge Zhang, Jianjun Guan, Yi Hong, and Jun Liao. Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs. Critical Review in Biomedical Engineering. 43(5-6): 455-471, 2016

        6.      William Zhang, Salma Ayoub, Jun Liao, Michael S. Sacks. A Meso-scale Layer-Specific Structural Constitutive Model of the Mitral Heart Valve Leaflets. Acta Biomaterialia. 32: 238–255, 2016

        7.       Rupak Dua, Kristin Comella,  J. Ryan Butler,  Glenda Castellanos,  Bryn Brazille,  Andrew Claude,  Arvind Agarwal,  Jun Liao,  Sharan Ramaswamy. Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles. PLOS ONE. 11 (2): e0149121, 2016

        8.      Amanda Pinheiro, Avery J. Cooley, Jun Liao, Raj Prabhu, and Steve Elder. Comparison of Natural Crosslinking Agents for the Stabilization of Xenogenic Cartilage. Journal of Orthopaedic Research. DOI:10.1002/jor.23121, 2016

        9.      MA Murphy, MF Horstemeyer, Steven R Gwaltney, Tonya Stone, Michelle LaPlaca, Jun Liao, Lakiesha Williams, R Prabhu. Nanomechanics of phospholipid bilayer failure under strip biaxial stretching using molecular dynamics. Modelling and Simulation in Materials Science and Engineering. 24 (5): 55008-55026, 2016

        10.   Erin Brinkman, Sourav Patnaik, Benjamin Weed, Bryn Brazile, Robert Wills, Nicholas Olivier, Dodd Sledge, Avery J. Cooley, Jun Liao, Ann Rashmir. Cardiac findings in horses with heritable equine regional dermal asthenia. Journal of the American Veterinary Medical Association. (In press, 2016)

        2015

        11.    Bryn Brazile, Bo Wang, Guangjun Wang, Robbin Bertucci, Raj Prabhu, Sourav Patnaik, J. Ryan Butler, Andrew Claude, Erin Brinkman-Ferguson, Lakiesha N. Williams, and Jun Liao. On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants. 25:1-14, 2015

        12.   Wuwei Li, Guowu Ma, Bryn Brazile, Nan Li, Wei Dai, J Ryan Butler, Andrew A Claude, Jason A Wertheim, Jun Liao, Bo Wang. Investigating the Potential of Amnion-Based Scaffolds as a Barrier Membrane for Guided Bone Regeneration. Langmuir. 31 (31): 8642-8653, 2015

        13.   John Clemmer, Raj Prabhu, Joseph Chen, Erin Colebeck, Lauren B Priddy, Michael McCollum, Bryn Brazile, Wilbur Whittington, Jennifer L Wardlaw, Hongjoo Rhee, M F Horstemeyer, Lakiesha N. Williams, Jun Liao. Experimental Observation of High Starin Rate Responses of Porcine Brain, Liver, and Tendon. Journal of Mechanics in Medicine and Biology, 1650032, 2015

        14.   Benjamin Weed, Sourav Patnaik, Mary Rougeau-Browning, Bryn Brazile, Jun Liao, Raj Prabhu, Lakiesha N. Williams. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 8 (5): 2454-2466, 2015

        15.   Raj Prabhu, W. R. Whittington, Sourav S. Patnaik, Y. Mao, Mark. T. Begonia, Lakiesha. N. Williams, Jun Liao, Mark F. Horstemeyer. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials. Journal of Visualized Experiments. 25(1–2): 41–53, 2015

        16.   Ali Azadi, Sourav S Patnaik, Jacek B Jasinski, Sean L Francis, Zhenmin Lei, Jun Liao, Nicolette E Deveneau, Donald R Ostergard. Morphologic Evaluation of Post-implanted Monofilament Polypropylene Mesh Utilizing a Novel Technique with Scanning Electron Microscopy Quantification. Surgical technology international. 26: 169-173, 2015

        17.   Chung-Hao Lee, Will Zhang, Jun Liao, Christopher A. Carruthers, Jacob I. Sacks, Michael S. Sacks. On the Presence of Affine Fibril and Fiber Kinematics in the Mitral Valve Anterior Leaflet. Biophysical journal. 108 (8), 2074-2087, 2015

        18.   Leslie N. Sierad, Eliza L. Shaw, Alexander Bina, Bryn Brazile, Nicholas Rierson, Sourav S. Patnaik, Agneta Simionescu, Jun Liao, Ionela Movileanu, Marius Harpa, Dan T. Simionescu. Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System. Tissue Eng Part C Methods. (Epub ahead of print, PMID: 26467108), 2015

        19.   Feize Li, Jijun Yang, Jiali Liao, Shoujian Li, Jun Liao, Raj Prabhu, Lakiesha N Williams, Yuanyou Yang, Jun Tang, Ning Liu. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 276: 322-330, 2015

        20.  Sourav S Patnaik, Bryn Brazile, Vani Dandolu, Peter L Ryan, Jun Liao. Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome: A historical perspective. Gene. Jan 15;555(1):33-40, 2015

        2014

        21.   Renee Pietsch, Benjamin B. Wheatley, Tammy L. Haut Donahue, Ryan Gilbrech, Raj Prabhu, Jun Liao, Lakiesha N William. The Anisotropic Compressive Properties of Porcine Muscle Tissue. Journal of Biomechanical Engineering. 136(11), 111003, 2014

        22.  Mark Begonia, Ruiyi Wu, Rajkumar Prabhu, Jun Liao, Wilburn R. Whittington, Andrew Claude, Bridget Willeford, Jennifer Wardlawe, Song Zhang, Lakiesha Williams. Quantitative Analysis of Rodent Brain Microstructure Following Mild Blunt and Blast Trauma. Journal of Biomechanics. 47:3704-3711, 2014

        23.  Yanyi Xu, Sourav Patnaik, Xiaolei Guo, Zhenqing Li, Wilson Lo, Ryan Butler, Andrew Claude, Zhenguo Liu, Ge Zhang, Jun Liao, Peter M Anderson, Jianjun Guan. Cardiac Differentiation of Cardiosphere-Derived Cells in Scaffolds Mimicking Morphology of the Cardiac Extracellular Matrix. Acta Biomaterialia. Aug;10(8):3449-62, 2014

        24.  Benjamin C. Weed, Toree L. Bova, Sourav S. Patnaik, Bryn Brazile, Cate Mochal-King, Bryan Rude, R. Prabhu, Lakiesha N. Williams, Jun Liao. 3D Printing–Assisted Rapid Prototyping and Optimization: Development of a Novel Small Intestinal Cannula for Equine Research. 3D Printing and Additive Manufacturing 1 (2), 104-106, 2014

        25.  Nayeon Lee, M. F. Horstemeyer, Hongjoo Rhee, Ben Nabors, Jun Liao, Lakiesha N. Williams. Hierarchical multiscale structure–property relationships of the red-bellied woodpecker (Melanerpes carolinus) beak. Journal of The Royal Society Interface 11 (96), 20140274, 2014

        26.  Alan D. Freed, Jun Liao, Daniel R. Einstein. A Membrane Model from Implicit Elasticity Theory: Application to Visceral Pleura. Biomechanics and Modeling in Mechanobiology. 13(4): 871-881, 2014

        27.   Kyle Johnson, Wes Trim, M. F. Horstemeyer, Nayeon Lee, Lakiesha Williams, Jun Liao, Hongjoo Rhee and R Prabhu. Geometric effects on stress wave propagation. Journal of Biomechanical Engineering. 136 (2), 021023, 2014

        28.  Valtresa Myles, Jun Liao, James N. Warnock. Cyclic Pressure and Angiotensin II Influence the Biomechanical Properties of Aortic Valves. Journal of Biomechanical Engineering. 136(1):011011, 2014

        2013

        29.  Bo Wang, Guangjun Wang, Filip To, J. Ryan Butler, Andrew Claude, Ronald M. McLaughlin, Lakiesha N. Williams, Amy L. de Jongh Curry, and Jun Liao. “Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations.” Langmuir. 29(35): 11109-17, 2013

        30.  Jeremy Mercuri, Sourav S Patnaik, Grace Dion, Sanjitpal Gill, Jun Liao, and Dan T. Simionescu. “Regenerative Potential of Decellularized Porcine Nucleus Pulposus Hydrogel Scaffolds; Stem cell Differentiation, Matrix Remodeling and Biocompatibility Studies.” Tissue Engineering Part A. Apr;19(7-8):952-66, 2013

        31.   James P. Chow, Dan T. Simionescu, Harleigh Warner, Bo Wang, Sourav S. Patnaik, Jun Liao, Agneta Simionescu, “Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol.” Biomaterials, Jan;34(3):685-95, 2013

        2012

        32.  Richard L. Summers, Weston Smith, Jun Liao Ryan Gilbrech, Benjamin C. Weed, Sourav Patnaik, and, “Influence Of Microgravity On Left Ventricular Sphericity: A Finite Element Model Of The Heart.” The American Institute of Aeronautics and Astronautics (AIAA) Journal, 2012

        33.  Bo Wang, Mary E. Tedder, Clara E. Perez, Guangjun Wang, Amy L. de Jongh Curry, Filip To, Steve H. Elder, Lakiesha N. Williams, Dan T. Simionescu, and Jun Liao. “Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix.” Journal of Materials Science – Materials in Medicine, Aug;23(8):1835-47, 2012

        34.  Benjamin C. Weed, Ali Borazjani, Sourav S. Patnaik, Rajkumar Prabhu, Mark F. Horstemeyer, Peter L. Ryan, Thomas Franz, Lakiesha N. Williams, Jun Liao. “Stress State and Strain Rate Dependence of the Human Placenta.” Annals of Biomedical Engineering, Oct;40(10):2255-65, 2012

        35.  Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao. “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.” Journal of Healthcare Engineering, 3(2): 179–202, 2012

        36.  Jun Liao, Erinn M. Joyce, W. David Merryman, Hugh L. Jones, Mina Tahai, Mark F. Horstemeyer, Lakiesha N. Williams, Richard A. Hopkins, and Michael S. Sacks. “The Intrinsic Fatigue Mechanism of Porcine Aortic Valve Extracellular Matrix.” Cardiovascular Engineering and Technology, 3(1):  62-72, 2012

        2011

        37.   Jianjun Guan, Feng Wang, Zhenqing Li, Joseph Chen, Xiaolei Guo, Jun Liao, Nicanor I. Moldovan. “The Stimulation of the Cardiac Differentiation of Mesenchymal Stem Cells in Tissue Constructs that Mimic Myocardium Structure and Biomechanics.” Biomaterials, 32(24):5568-80, 2011

        38.  R. Prabhu, M.F. Horstemeyer, M. Tucker, E.B. Marin, J.L. Bouvard, J. Sherburn, Jun Liao, Lakiesha Williams. “Coupled Experiment/Finite Element Analysis on the Mechanical Response of Porcine Brain under High Strain Rates” Journal of the Mechanical Behavior of Biomedical Materials, 4(7):1067-80, 2011

        39.  Ali Borazjani, Benjamin Weed, Sourav Patnaik, Jean Feugang, David Christiansen, Steven H. Elder, Peter L. Ryan, and Jun Liao. “A Comparative Biomechanical Analysis of Term Fetal Membranes in Human and Domestic Species.” American Journal of Obstetrics and Gynecology, 204(4):365.e25-36, 2011

        40.  K. Jane Grande-Allen and Jun Liao. “The Heterogeneous Biomechanics and Mechanobiology of the Mitral Valve: Implications for Tissue Engineering.” Current Cardiology Reports, 13(2):113-20, 2011

        41.   Mary E. Tedder, Agneta Simionescu, Joseph Chen, Jun Liao, Dan T. Simionescu. “Assembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering.” TISSU ENGINEERING Part A, 17(1-2):25-36, 2011

        42.  Wes Trim, Mark F. Horstemeyer, Hongjoo Rhee, Seong-Jin Park, Haitham El Kadiri, Lakiesha Williams, Jun Liao, and Joanna McKittrick. “Parametric study of the structure-property relations of bighorn sheep (Ovis canadensis) horn” Acta Biomaterialia, 7(3):1228-40, 2011

        43.  Emanuel Villa, Alayne Stewart White, Jun Liao, and Amy L. de Jongh Curry. "An Inexpensive Alternative Bath System for Electrophysiological Characterization of Isolated Cardiac Tissue." IEEE Eng Med Biol Soc: page: 8424-7, 2011

        2010

        44.  John Clemmer, Jun Liao, Debbie Davis, Mark F. Horstemeyer, and Lakiesha Williams. “A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon.” JOURNAL OF BIOMECHANICS, 43(14):2785-91, 2010

        45.  Leslie N Sierad, Agneta Simionescu, Joseph Chen, Christopher Albers, Jordan Maivelett, Mary E Tedder, Jun Liao, Dan T. Simionescu. “Design and testing of a pulsatile conditioning system for dynamic endothelialization of polyphenol-stabilized tissue engineered heart valves.” Cardiovascular Engineering and Technology, Vol. 1 (2): 138–153, 2010

        46.  Bo Wang, Ali Borazjani, Mina Tahai, Amy L. de Jongh Curry, Dan T. Simionescu, Jianjun Guan, Filip To, Steve H. Elder, and Jun Liao. “Fabrication of Cardiac Patch with Decellularized Porcine Myocardial Scaffold and Bone Marrow Mononuclear Cells.” JOURNAL OF BIOMEDICAL MATERIALS RESEARCH Part A, 15;94(4):1100-10, 2010

        47.   Mark T. Begonia, Raj Prabhu, Jun Liao, Mark F. Horstemeyer Lakiesha N. Williams. “The influence of strain rate dependency on the structure-property relations of porcine brain.” ANNALS OF BIOMEDICAL ENGINEERING, 38(10):3043-57, 2010

        48.  Song Zhang, J. Allen Crow, Xiaoyong Yang, Joseph Chen, Ali Borazjani, Katie B Mullins, Wei Chen, Robert C. Cooper, Ronald M. McLaughlin, Jun Liao. “The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium.” ANNALS OF BIOMEDICAL ENGINEERING, 38(10):3084-95, 2010

        49.  James Warnock, Carol Pregonero Gamez, Scott Metzler, Joseph Chen, Steven Elder, and Jun Liao. Vasoactive Agents Alter the biomechanical Properties of Aortic Heart Valve Learlets in a Time-dependent Manner, JOURNAL OF HEART VALVE DISEASE, 19(1): 86-96, 2010

        2009

        50.  Wei Chen, Zhicheng Yan, Song Zhang, John A. Crow, Ronald M. McLaughlin, Katie B. Mullins, Robert Cooper, David Ebert, Zi’ang Ding, and Jun Liao,. Modeling and Illustration of Muscle from Diffusion Tensor Images. IEEE Transactions on Visualization and Computer Graphics, 15(6):1425-32, 2009

        51.   Jun Liao, Lauren B. Priddy, Bo Wang, Joseph Chen, and Ivan Vesely. “Ultrastructure of Porcine Mitral Valve Chordae Tendineae.” JOURNAL OF HEART  VALVE DISEASE, 18(3), 292-299, 2009

        52.  Erin M. Joyce, Jun Liao, John E. Mayer, Michael S. Sacks. Effects of Transvalvular Pressure on Pulmonary Valve Microstructure, ANNALS OF THORACIC SURGERY. 87(4):1240-9, 2009

        53.  Corin Williams, Jun Liao, Erinn M. Joyce, Bo Wang, Jennie B. Leach, Michael S. Sacks, and Joyce Y. Wong. “Structural and Mechanical Properties of Decellularized Rabbit Carotid Arteries.” ACTA BIOMATERIALIA, 5(4):993-1005, 2009

        54.  Mary E. Tedder, Jun Liao, Benjamin Weed, Christopher Stabler, Henry Zhang, Agneta Siminonescu, and Dan T. Siminonescu. “Stabilized acellular pericardium: novel collagen scaffold for heart valve tissue engineering.” TISSU ENGINEERING Part A, 15(6):1257-68, 2009

        2008

        55.   Jun Liao, Erin M. Joyce, Michael S. Sacks. Effects of decellularization on mechanical and structural properties of the porcine aortic valve leaflets, BIOMATERIALS. Mar; 29(8):1065-74, 2008.

        56.  John A. Stella, Jun Liao, Yi Hong, W. David Merryman, William R. Wagner, and Michael S. Sacks. Tissue-Cellular Deformation Coupling in Cell-Micro integrated Electrometric Scaffolds. BIOMATERIALS. 29(22):3228-36, 2008

        57.   Pietro Bajona, Kenton J. Zehr, Jun Liao, Giovanni Speziali. “Tension Measurement of Artificial Chordae Tendineae Implanted Between the Anterior Mitral Valve Leaflet and the Left Ventricular Apex: An In Vitro Study.” INNOVATIONS: Technology and Techniques in Cardiothoracic and Vascular Surgery. Vol. 3 (1) 33-37, 2008

        2007

        58.  Jun Liao, Lin Yang, Jonathan S. Grashow, Michael S. Sacks. "The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leaflet," JOURNAL OF BIOMECHANICAL ENGINEERING, Feb; 129 (1):78-87, 2007

        59.  Jun Liao, Ivan Vesely. "Skewness Angle of Interfibrillar Proteoglycans Increases with Applied Load on Chordae Tendineae." JOURNAL OF BIOMECHANICS, 40(2):390-8, 2007

        60.  John A. Stella, Jun Liao, and Michael S. Sacks. "Time dependent biaxial mechanical behavior of the aortic heart valve leaflet." JOURNAL OF BIOMECHANICS, 40(14):3169-77, 2007

        61.   W. David Merryman, Jun Liao, Aeron Parekh, Joseph E. Candiello, Hai Lin, Michael S. Sacks. "The Heart Valve Interstitial Cell Cytoskeleton: Role in Cell Stiffness, Contraction and Tissue Remodeling," TISSUE ENGINEERING 13 (9): 2281-2289 SEP 2007

        62.  H.Y. Shadow Huang, Jun Liao, and Michael S. Sacks. "In-situ deformation of the aortic heart valve interstitial cell nucleus under diastolic loading." JOURNAL OF BIOMECHANICAL ENGINEERING 129(6):880, 2007

        2003-2006

        63.  Jonathan S. Grashow, Michael S. Sacks, Jun Liao, Ajit P. Yoganathan. "Planar biaxial creep and stress relaxation of the mitral valve anterior leaflets." ANNALS OF BIOMEDICAL ENGINEERING Oct; 34 (10): 1509-18, 2006

        64.  W. David Merryman, George C. Engelmayr, Jun Liao, and Michael S. Sacks. "Defining Biomechanical Endpoints for Tissue Engineered Heart Valve Leaflets from Native Leaflet Properties." PROGRESS IN PEDIATRIC CARDIOLOGY Vol. 21, pp. 153-60, 2006

        65.  Jun Liao, Lin Yang, Jonathan S. Grashow, Michael S. Sacks. "Molecular orientation of collagen in intact planar connective tissue under biaxial stretch." ACTA BIOMATERIALIA, Vol. 1, p. 45-54, 2005

        66.  Jun Liao, Ivan Vesely. "The relationship between collagen fibrils, glycosaminoglycans and stress relaxation in mitral valve chordae tendineae." ANNALS OF BIOMEDICAL ENGINEERING Jul;32(7):977-83, 2004

        67.  Jun Liao, Ivan Vesely. "A structural basis for the size-related mechanical properties of mitral valve chordae tendineae." JOURNAL OF BIOMECHANICS 36/8: p1125-1133, 2003

        {Journal Article }

Courses

      • BE 4314-011 BIOMEDICAL IMPLANTS

        This comprehensive course covers the essential knowledge in biomedical implants. Our goal is to provide the students with knowledge and skills in understanding the medical need, engineering principles in implant design, host-implant interaction, engineering restrictions and non-engineering restrictions in design optimization, and implant performance/clinical outcome assessments. Case studies include mechanical, bioprosthetic and transcatheter heart valves, vascular grafts, stents, pacemakers, orthopedic implants, dental implants, etc. In this course, we also cover the regulatory knowledge such as patent protection, design validation in animal models and clinical trials, IACUC, IRB, Good Manufacture Practice (GMP), and FDA regulations and approvals.

        Spring - Regular Academic Session - 2018 Download Syllabus Contact info & Office Hours
      • BE 5314-011 BIOMEDICAL IMPLANTS

        This comprehensive course covers the essential knowledge in biomedical implants. Our goal is to provide the students with knowledge and skills in understanding the medical need, engineering principles in implant design, host-implant interaction, engineering restrictions and non-engineering restrictions in design optimization, and implant performance/clinical outcome assessments. Case studies include mechanical, bioprosthetic and transcatheter heart valves, vascular grafts, stents, pacemakers, orthopedic implants, dental implants, etc. In this course, we also cover the regulatory knowledge such as patent protection, design validation in animal models and clinical trials, IACUC, IRB, Good Manufacture Practice (GMP), and FDA regulations and approvals.

        Spring - Regular Academic Session - 2018 Download Syllabus Contact info & Office Hours
      • BE 5312-011 TISSUE BIOMECHANICS AND BIOENGINEERING

        This course introduces biomechanics as a means to describe mechanical behavior of biological tissues. We cover the fundamental concepts, experimental and theoretical approaches of biomechanics, and their applications in modern bioengineering (e.g., physiology, pathophysiology, mechanotransduction, tissue engineering and regeneration, medical implants, surgical intervention). Structural-mechanical properties of specific tissues, such as heart valves, cardiac tissues, blood vessels, tendon/ligament, skeletal muscles, cartilage, and meniscus, will be discussed in great details.

        Fall - Regular Academic Session - 2017 Download Syllabus Contact info & Office Hours
      • BE 4312-011 TISSUE BIOMECHANICS AND BIOENGINEERING

        This course introduces biomechanics as a means to describe mechanical behavior of biological tissues. We cover the fundamental concepts, experimental and theoretical approaches of biomechanics, and their applications in modern bioengineering (e.g., physiology, pathophysiology, mechanotransduction, tissue engineering and regeneration, medical implants, surgical intervention). Structural-mechanical properties of specific tissues, such as heart valves, cardiac tissues, blood vessels, tendon/ligament, skeletal muscles, cartilage, and meniscus, will be discussed in great details.

        Fall - Regular Academic Session - 2017 Download Syllabus Contact info & Office Hours
      • BE 5101-011 SEMINAR IN BIOENGINEERING

        University and guest lecturers speak on topics of current interest in the field of bioengineering.

        Fall - Regular Academic Session - 2017 Download Syllabus Contact info & Office Hours