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Dr Marco Brotto

[Dr Marco Brotto]

Professor
Last Updated: October 28, 2021
about me

Appointments

Appointments

    • Nov 2019 to Present Adjunct Professor
      Department of Health Sciences, University of Eastern Piedmont, Italy (Piazza, Novara, Italy)
      I am a advisor to the emerging PhD Program in Physical and Rehabilitation Medicine, and I have developed some very important colllaborations with Professor Marco Invernizzi, MD, PhD, which have now extended to the University of Milan.
    • Aug 2015 to Present George & Mary Hazel Jay Endowed Professor, Director of the Bone-Muscle Collabrative Sciences, Director of the PHD in Nursing Program
      ollege of Nursing & Health Innovation, University of Texas at Arlington
    • Past to Dec 2018 Nominated Director of new Bone-Muscle Research Center
    • Past to Sept 2017 Adjunct Professor
      Oral Biology Department, University of Missouri-Kansas City
    • Past to Sept 2017 Adjunct Projessor
      Ramon Regeneration Center, University of Texas Southwestern, Dallas, TX.
    • Sept 2012 to Aug 2015 Dale & Dorothy Thompson Missouri Endowed Professor of Nursing Research And Professor of Nursing
      Medicine, and Pharmacology, Director of MUBIG, UMKC.
    • Past to Sept 2011 Tenured Professor of Nursing and Medicine and Director of MUBIG
    • Past to Feb 2010 Director
      FTC Biomedicine Center, (Salvador, Brazil)
    • Past to Feb 2009 Director
      UMKC Muscle Biology Research Group-MUBIG.
    • 2003 to 2007 Assistant Professor
      Dept. of Physiology and Biophysics, Robert Wood Johnson Medical School
    • Past to Aug 2007 Associate Professor
      Nursing and Medicine, University of Missouri at Kansas City (UMKC) (Kansas City, MO)
    • 2000 to 2003 Instructor of Physiology and Biophysics
      School of Medicine, Dept. of Physiology and Biophysics, Case Western Reserve University (Cleveland, OH)

Memberships

    • Past to 2019 American Physiological Society
    • 2008 to 2015 American Physiological Society Muscle Biology Group
      Co-Director with Dr. Thomas Nosek

Awards and Honors

    • Sep  2020 Appointed as Associated Editor sponsored by Frontiers in Aging
    • Jun  2019 Adjunct Appointment sponsored by University of Eastern Piedmont, Italy
    • Jul  2018 Director sponsored by Musculoskeletal Research Center-MUREC
    • May  2018 Second Endowment at UTA sponsored by Evanson Nursing Research Endowment
    • Sep  2017 Adjunct Appointments sponsored by UMKC and UT-Southwestern
    •  2015 1st UTA College of Nursing Faculty awarded with the University of Texas Wide System STARS award sponsored by University of Texas
    •  2015 Director of the Bone-Muscle Collaborative Group sponsored by UTA
    •  2013 Selected by Abbott Nutrition and Ross Labs as part of the Muscle Biology 14-Labs International Consortia sponsored by International Consortia
    •  2012 Guest Editor of Special Edition on Muscle Diseases in Recent Patents on Biotechnology sponsored by Muscle Diseases in Recent Patents on Biotechnology
    •  2011 Tenure sponsored by Promoted to Full Professor
    •  2010 Outstanding Scholar Award sponsored by UMKC School of Nursing
    •  2009 International Visiting Professor and Scholar sponsored by Brazilian Council for Research, Brazil
    •  2009 Scientific Director of the Center for Biomedical Research at the College of Sciences & Technology sponsored by Salvador, Bahia, Brazil

Support & Funding

Support & Funding

This data is entered manually by the author of the profile and may duplicate data in the Sponsored Projects section.
    • Sept 2018 to May 2023 Regulation of Store-Operated Calcium Entry during Muscle Aging sponsored by  -  $1005735
      Marco Brotto (Funded)
    • Sept 2018 to May 2022 Osteocyte Regulation of Bone/Muscle with Aging-Project 2 sponsored by  -  $1514859
      Marco Brotto (Funded)
    • July 2018 to May 2022 Loss of Numb in Muscle Dysfunction in Aging sponsored by  -  $780332
      Marco Brotto (Funded)
    • June 2019 to Mar 2022 Preserving mitochondrial function for alleviating ALS progression sponsored by  -  $1752752
      (Funded)
    • Apr 2019 to Mar 2022 Protecting the diabetic skeletal muscle by Nampt activation sponsored by  -  $438774
      Marco Brotto (Funded)
    • Sept 2019 to Aug 2021 R56 - Printing and Regenerating Fractured Bone Using Antioxidant Materials sponsored by  -  $427584
      (Funded)
    • Apr 2016 to Mar 2022 Targeting Sympathetic Overactivity in CKD patients: Mechanisms & Novel Therapies sponsored by  -  $1700916
      (Funded)
    • June 2016 to May 2018 KLF15 and Transcriptional Control of Muscle Metabolism sponsored by  -  $51492
      Marco Brotto (Funded)
    • Aug 2015 to Aug 2018 Osteocyte Regulation of Bone Muscle with Age sponsored by  -  $415732
      Marco Brotto (Funded)
    • Sept 2015 to Aug 2016 MG29 function in regulation of store-operated calcium entry during muscle aging sponsored by  -  $181200
      Marco Brotto (Funded)

Publications


      In Process
      • Journal Article
        Novel 3D-printed methacrylated chitosan-laponite nanosilicate composite scaffolds enhance cell growth and biomineral formation in MC3T3 pre-osteoblasts
        [Cebe, Tugba, Ahuja, Neelam, Monte, Felipe, Awad, Kamal, Vyavhare, Kimaya, Aswath, PraneshB, Huang, Jian, Brotto, Marco, Varanasi, VenuGopal]. Journal of Materials Research. 1-18. "Cambridge University Press (CUP)". DOI: http://dx.doi.org/10.1557/jmr.2018.260
        http://dx.doi.org/10.1557/jmr.2018.260 Published.
      • Journal Article
        Temporal Effects of Stress by Immobilization and Sensitivity of the Isolated Rat Pacemaker to Isoproterenol: Roles of Corticosterone, Neuronal Uptake, and  -Adrenergic Homogeneity
        [de Paula Brotto, M.A.]. Journal of Pharmacology and Experimental Therapeutics. 306(3), 1152-1158. "American Society for Pharmacology & Experimental Therapeutics (ASPET)". DOI: http://dx.doi.org/10.1124/jpet.103.052670
        http://dx.doi.org/10.1124/jpet.103.052670 Published.
      • Journal Article
        The relative efficacy of two exercise methods for older adults with chronic low back pain: A preliminary randomized control study
        [Salas, Eric, Hulla, Ryan, Vanzzini, Nikeis, Trowbridge, Cynthia, Brotto, Marco, Keller, DavidM, Gatchel, RobertJ]. Journal of Applied Biobehavioral Research. e12132. "Wiley". DOI: http://dx.doi.org/10.1111/jabr.12132
        http://dx.doi.org/10.1111/jabr.12132 Published.

      2020
      • Journal Article
        Deletion of SREBF1, a functional bone-muscle pleiotropic gene, alters bone density and lipid signaling in zebrafish.
        [Shochat, C, Wang, Z, Mo, C, Nelson, S, Donaka, R, Huang, J, Karasik, D, Brotto, M]. Endocrinology. DOI: http://dx.doi.org/10.1210/endocr/bqaa189
      • Journal Article
        New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse.
        [Biguetti, CC, Couto MCR, Silva ACR, Shindo JVTC, Rosa, VM, Shinohara, AL, Andreo, JC, Duarte MAH, Wang, Z, Brotto, M, Matsumoto, MA]. 11, 484. DOI: http://dx.doi.org/10.3389/fendo.2020.00484
      • Journal Article
        The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression.
        [Marrelli, MT, Wang, Z, Huang, J, Brotto, M]. Malaria Journal. 19(1), 254. DOI: http://dx.doi.org/10.1186/s12936-020-03332-3
      • Journal Article
        Rats genetically selected for low and high aerobic capacity exhibit altered soleus muscle myofilament functions.
        [Biesiadecki, BJ, Brotto, MA, Brotto, LS, Koch, LG, Britton, SL, Nosek, TM, Jin, JP]. American Journal of Physiology. Cell Physiology. 318(2), C422-C429. DOI: http://dx.doi.org/10.1152/ajpcell.00430.2019
      • Journal Article
        Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis.
        [Wang, Z, Bian, L, Mo, C, Shen, H, Zhao, LJ, Su, KJ, Kukula, M, Lee, JT, Armstrong, DW, Recker, R, Lappe, J, Bonewald, LF, Deng, HW, Brotto, M]. 3(1), 39. DOI: http://dx.doi.org/10.1038/s42003-020-0766-y
      • Journal Article
        Amorphous Silicon Oxynitrophosphide-Coated Implants Boost Angiogenic Activity of Endothelial Cells.
        [Monte FAD, Awad, KR, Ahuja, N, Kim HKW, Aswath, P, Brotto, M, Varanasi, VG]. 26(1-2), 15-27. DOI: http://dx.doi.org/10.1089/ten.TEA.2019.0051

      2019
      • Journal Article
        Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells.
        [Huang, J, Wang, K, Shiflett, LA, Brotto, L, Bonewald, LF, Wacker, MJ, Dallas, SL, Brotto, M]. 18(24), 3562-3580. DOI: http://dx.doi.org/10.1080/15384101.2019.1691796
      • Journal Article
        Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways.
        [Mo, C, Wang, Z, Bonewald, L, Brotto, M]. 20(18), DOI: http://dx.doi.org/10.3390/ijms20184326
      • Journal Article
        Neural control of postural sway: Relationship to strength measures in young and elderly adults.
        [King, GW, Abreu, EL, Kelly, PJ, Brotto, M]. Experimental Gerontology. 118, 39-44. DOI: http://dx.doi.org/10.1016/j.exger.2019.01.005
      • Journal Article
        Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes.
        [Maurel, DB, Matsumoto, T, Vallejo, JA, Johnson, ML, Dallas, SL, Kitase, Y, Brotto, M, Wacker, MJ, Harris, MA, Harris, SE, Bonewald, LF]. 7, 6. DOI: http://dx.doi.org/10.1038/s41413-018-0037-4

      2018
      • Journal Article
        Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility.
        [Avin, KG, Vallejo, JA, Chen, NX, Wang, K, Touchberry, CD, Brotto, M, Dallas, SL, Moe, SM, Wacker, MJ]. American Journal of Physiology: Endocrinology and Metabolism. 315(4), E594-E604. DOI: http://dx.doi.org/10.1152/ajpendo.00343.2017
      • Journal Article
        Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation.
        [Chapalamadugu, KC, Tur, J, Badole, SL, Kukreja, RC, Brotto, Marco, Tipparaju, SM]. 224(2), e13083. DOI: http://dx.doi.org/10.1111/apha.13083
      • Journal Article
        Nanodrug delivery platform for glucocorticoid use in skeletal muscle injury.
        [Sutariya, V, Tur, J, Kelly, S, Halasz, K, Chapalamadugu, KC, Nimbalkar, R, Pathak, YV, Weigel, R, Daviau, T, Webb, T, Cacace, J, Brotto, M, Tipparaju, SM]. Canadian Journal of Physiology and Pharmacology. 96(7), 681-689. DOI: http://dx.doi.org/10.1139/cjpp-2017-0795
      • Journal Article
        Nanodrug delivery platform for glucocorticoid use in skeletal muscle injury.
        [Sutariya, V, Tur, J, Kelly, S, Halasz, K, Chapalamadugu, KC, Nimbalkar, R, Pathak, YV, Weigel, R, Daviau, T, Webb, T, Cacace, J, Brotto, Marco, Tipparaju, SM]. Canadian Journal of Physiology and Pharmacology. 96(7), 681-689. DOI: http://dx.doi.org/10.1139/cjpp-2017-0795
      • Journal Article
        Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain.
        [Gatchel, RJ, Bevers, K, Licciardone, JC, Su, J, Du , Y, Brotto, M]. 6(2), DOI: http://dx.doi.org/10.3390/healthcare6020048
      • Journal Article
        β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor.
        [Kitase, Y, Vallejo, JA, Gutheil, W, Vemula, H, Jähn, K, Yi, Jianxun, Zhou, Jingsong, Brotto, Marco, Bonewald, LF]. Cell Reports. 22(6), 1531-1544. DOI: http://dx.doi.org/10.1016/j.celrep.2018.01.041

      2017
      • Journal Article
        Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway.
        [Huang, J, Romero-Suarez, S, Lara, N, Mo, C, Kaja, S, Brotto, L, Dallas, SL, Johnson, ML, Jähn, K, Bonewald, LF, Brotto, M]. 1(2), 86-100. DOI: http://dx.doi.org/10.1002/jbm4.10015
      • Journal Article
        Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway.
        [Huang, Jian, Romero-Suarez, S, Lara, N, Mo, Chenglin, Kaja, S, Brotto, L, Dallas, SL, Johnson, ML, Jähn, K, Bonewald, LF, Brotto, Marco]. 1(2), 86-100. DOI: http://dx.doi.org/10.1002/jbm4.10015
      • Journal Article
        Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia.
        [Bhan, A, Deb, P, Shihabeddin, N, Ansari, KI, Brotto, M, Mandal, SS]. Gene. 629, 16-28. DOI: http://dx.doi.org/10.1016/j.gene.2017.07.069
      • Journal Article
        Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia.
        [Bhan, A, Deb, P, Shihabeddin, N, Ansari, KI, Brotto, Marco, Mandal, SubhrangsuS]. Gene. 629, 16-28. DOI: http://dx.doi.org/10.1016/j.gene.2017.07.069
      • Journal Article
        Targeted quantification of lipid mediators in skeletal muscles using restricted access media-based trap-and-elute liquid chromatography-mass spectrometry.
        [Wang, Z, Bian, L, Mo, C, Kukula, M, Schug, KA, Brotto, M]. Analytica Chimica Acta. 984, 151-161. DOI: http://dx.doi.org/10.1016/j.aca.2017.07.024
      • Journal Article
        Targeted quantification of lipid mediators in skeletal muscles using restricted access media-based trap-and-elute liquid chromatography-mass spectrometry.
        [Wang, Zhijun, Bian, L, Mo, Chenglin, Kukula, M, Schug, KevinA, Brotto, Marco]. Analytica Chimica Acta. 984, 151-161. DOI: http://dx.doi.org/10.1016/j.aca.2017.07.024

      2016
      • Journal Article
        Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets.
        [Wacker, MJ, Touchberry, CD, Silswal, N, Brotto, L, Elmore, CJ, Bonewald, LF, Andresen, J, Brotto, M]. Frontiers in Physiology. 7, 173. DOI: http://dx.doi.org/10.3389/fphys.2016.00173
      • Journal Article
        Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets.
        [Wacker, MJ, Touchberry, CD, Silswal, N, Brotto, L, Elmore, CJ, Bonewald, LF, Andresen, J, Brotto, Marco]. Frontiers in Physiology. 7, 173. DOI: http://dx.doi.org/10.3389/fphys.2016.00173
      • Journal Article
        A multimodal assessment of balance in elderly and young adults.
        [King, GW, Abreu, EL, Cheng, AL, Chertoff, KK, Brotto, L, Kelly, PJ, Brotto, M]. Oncotarget. 7(12), 13297-306. DOI: http://dx.doi.org/10.18632/oncotarget.7758
      • Journal Article
        A multimodal assessment of balance in elderly and young adults.
        [King, GW, Abreu, EL, Cheng, AL, Chertoff, KK, Brotto, L, Kelly, PJ, Brotto, Marco]. Oncotarget. 7(12), 13297-306. DOI: http://dx.doi.org/10.18632/oncotarget.7758
      • Journal Article
        Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice.
        [Vallejo, J, Spence, M, Cheng, AL, Brotto, L, Edens, NK, Garvey, SM, Brotto, M]. PLoS One. 11(3), e0150066. DOI: http://dx.doi.org/10.1371/journal.pone.0150066
      • Journal Article
        Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice.
        [Vallejo, J, Spence, M, Cheng, AL, Brotto, L, Edens, NK, Garvey, SM, Brotto, Marco]. PLoS One. 11(3), e0150066. DOI: http://dx.doi.org/10.1371/journal.pone.0150066
      • Journal Article
        Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.
        [Gorski, JP, Huffman, NT, Vallejo, J, Brotto, L, Chittur, SV, Breggia, A, Stern, A, Huang, J, Mo, C, Seidah, NG, Bonewald, L, Brotto, M]. The Journal of Biological Chemistry. 291(9), 4308-22. DOI: http://dx.doi.org/10.1074/jbc.M115.686626
      • Journal Article
        Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.
        [Gorski, JP, Huffman, NT, Vallejo, J, Brotto, L, Chittur, SV, Breggia, A, Stern, A, Huang, Jian, Mo, Chenglin, Seidah, NG, Bonewald, L, Brotto, Marco]. The Journal of Biological Chemistry. 291(9), 4308-22. DOI: http://dx.doi.org/10.1074/jbc.M115.686626

      2015
      • Journal Article
        ITS and trnH-psbA as Efficient DNA Barcodes to Identify Threatened Commercial Woody Angiosperms from Southern Brazilian Atlantic Rainforests.
        [Bolson, M, Smidt Ede, C, Brotto, Marco, Silva-Pereira, V]. PLoS One. 10(12), e0143049. DOI: http://dx.doi.org/10.1371/journal.pone.0143049
      • Journal Article
        The family series workshop: a community-based psychoeducational intervention.
        [Llanque, SM, Enriquez, M, Cheng, AL, Doty, L, Brotto, MA, Kelly, PJ, Niedens, M, Caserta, MS, Savage, LM]. 30(6), 573-83. DOI: http://dx.doi.org/10.1177/1533317514568003
      • Journal Article
        The family series workshop: a community-based psychoeducational intervention.
        [Llanque, SM, Enriquez, M, Cheng, AL, Doty, L, Brotto, Marco, Kelly, PJ, Niedens, M, Caserta, MS, Savage, LM]. 30(6), 573-83. DOI: http://dx.doi.org/10.1177/1533317514568003
      • Journal Article
        Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
        [Mo, C, Zhao, R, Vallejo, J, Igwe, O, Bonewald, L, Wetmore, L, Brotto, M]. 14(10), 1507-16. DOI: http://dx.doi.org/10.1080/15384101.2015.1026520
      • Journal Article
        Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
        [Mo, Chenglin, Zhao, R, Vallejo, J, Igwe, O, Bonewald, L, Wetmore, L, Brotto, Marco]. 14(10), 1507-16. DOI: http://dx.doi.org/10.1080/15384101.2015.1026520

      2014
      • Journal Article
        SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.
        [Mukai, T, Ishida, S, Ishikawa, R, Yoshitaka, T, Kittaka, M, Gallant, R, Lin, YL, Rottapel, R, Brotto, M, Reichenberger, EJ, Ueki, Y]. 29(12), 2618-35. DOI: http://dx.doi.org/10.1002/jbmr.2295
      • Journal Article
        SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.
        [Mukai, T, Ishida, S, Ishikawa, R, Yoshitaka, T, Kittaka, M, Gallant, R, Lin, YL, Rottapel, R, Brotto, Marco, Reichenberger, EJ, Ueki, Y]. 29(12), 2618-35. DOI: http://dx.doi.org/10.1002/jbmr.2295
      • Journal Article
        METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.
        [Huang, J, Hsu, YH, Mo, C, Abreu, E, Kiel, DP, Bonewald, LF, Brotto, M, Karasik, D]. 29(7), 1531-1540. DOI: http://dx.doi.org/10.1002/jbmr.2200
      • Journal Article
        METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.
        [Huang, Jian, Hsu, YH, Mo, Chenglin, Abreu, E, Kiel, DP, Bonewald, LF, Brotto, Marco, Karasik, D]. 29(7), 1531-1540. DOI: http://dx.doi.org/10.1002/jbmr.2200
      • Journal Article
        Extracellular Membrane Vesicles Derived from 143B Osteosarcoma Cells Contain Pro-Osteoclastogenic Cargo: A Novel Communication Mechanism in Osteosarcoma Bone Microenvironment.
        [Garimella, R, Washington, L, Isaacson, J, Vallejo, J, Spence, M, Tawfik, O, Rowe, P, Brotto, M, Perez, R]. 7(3), 331-40. DOI: http://dx.doi.org/10.1016/j.tranon.2014.04.011
      • Journal Article
        Extracellular Membrane Vesicles Derived from 143B Osteosarcoma Cells Contain Pro-Osteoclastogenic Cargo: A Novel Communication Mechanism in Osteosarcoma Bone Microenvironment.
        [Garimella, R, Washington, L, Isaacson, J, Vallejo, J, Spence, M, Tawfik, O, Rowe, P, Brotto, Marco, Perez, R]. 7(3), 331-40. DOI: http://dx.doi.org/10.1016/j.tranon.2014.04.011
      • Journal Article
        A randomized-controlled trial pilot study examining the neurodevelopmental effects of a 5-week M Technique intervention on very preterm infants.
        [Smith, JR, McGrath, J, Brotto, M, Inder, T]. 14(3), 187-200. DOI: http://dx.doi.org/10.1097/ANC.0000000000000093
      • Journal Article
        A randomized-controlled trial pilot study examining the neurodevelopmental effects of a 5-week M Technique intervention on very preterm infants.
        [Smith, Jeremy, McGrath, J, Brotto, Marco, Inder, T]. 14(3), 187-200. DOI: http://dx.doi.org/10.1097/ANC.0000000000000093
      • Journal Article
        Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer.
        [Chou, WC, Cheng, AL, Brotto, M, Chuang, CY]. BMC Genomics. 15, 300. DOI: http://dx.doi.org/10.1186/1471-2164-15-300
      • Journal Article
        Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer.
        [Chou, WC, Cheng, AL, Brotto, Marco, Chuang, CY]. BMC Genomics. 15, 300. DOI: http://dx.doi.org/10.1186/1471-2164-15-300
      • Journal Article
        Skeletal muscle troponin as a novel biomarker to enhance assessment of the impact of strength training on fall prevention in the older adults.
        [Abreu, EL, Cheng, AL, Kelly, PJ, Chertoff, K, Brotto, L, Griffith, E, Kinder, G, Uridge, T, Zachow, R, Brotto, M]. 63(2), 75-82. DOI: http://dx.doi.org/10.1097/NNR.0000000000000018
      • Journal Article
        Skeletal muscle troponin as a novel biomarker to enhance assessment of the impact of strength training on fall prevention in the older adults.
        [Abreu, EL, Cheng, AL, Kelly, PJ, Chertoff, K, Brotto, L, Griffith, E, Kinder, G, Uridge, T, Zachow, R, Brotto, Marco]. 63(2), 75-82. DOI: http://dx.doi.org/10.1097/NNR.0000000000000018
      • Journal Article
        Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.
        [Manring, H, Abreu, E, Brotto, L, Weisleder, N, Brotto, M]. Frontiers in Physiology. 5, 37. DOI: http://dx.doi.org/10.3389/fphys.2014.00037
      • Journal Article
        Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.
        [Manring, H, Abreu, E, Brotto, L, Weisleder, N, Brotto, Marco]. Frontiers in Physiology. 5, 37. DOI: http://dx.doi.org/10.3389/fphys.2014.00037

      2013
      • Journal Article
        Outcomes of Stay Strong, Stay Healthy in community settings.
        [Ball, S, Gammon, R, Kelly, PJ, Cheng, AL, Chertoff, K, Kaume, L, Abreu, EL, Brotto, M]. Journal of Aging and Health. 25(8), 1388-97. DOI: http://dx.doi.org/10.1177/0898264313507318
      • Journal Article
        Outcomes of Stay Strong, Stay Healthy in community settings.
        [Ball, S, Gammon, R, Kelly, PJ, Cheng, AL, Chertoff, K, Kaume, L, Abreu, EL, Brotto, Marco]. Journal of Aging and Health. 25(8), 1388-97. DOI: http://dx.doi.org/10.1177/0898264313507318
      • Journal Article
        A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation.
        [Leon-Salas, WD, Rizk, H, Mo, C, Weisleder, N, Brotto, L, Abreu, E, Brotto, M]. 7(1), 71-81. DOI: http://dx.doi.org/10.2174/1872208311307010007
      • Journal Article
        A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation.
        [Leon-Salas, WD, Rizk, H, Mo, Chenglin, Weisleder, N, Brotto, L, Abreu, E, Brotto, Marco]. 7(1), 71-81. DOI: http://dx.doi.org/10.2174/1872208311307010007
      • Journal Article
        Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.
        [Tjondrokoesoemo, A, Li , N, Lin, PH, Pan, Z, Ferrante, CJ, Shirokova, N, Brotto, M, Weisleder, N, Ma, J]. The Journal of Biological Chemistry. 288(4), 2103-9. DOI: http://dx.doi.org/10.1074/jbc.M112.425975
      • Journal Article
        Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.
        [Tjondrokoesoemo, A, Li , N, Lin, PH, Pan, Zui, Ferrante, CJ, Shirokova, N, Brotto, Marco, Weisleder, N, Ma, J]. The Journal of Biological Chemistry. 288(4), 2103-9. DOI: http://dx.doi.org/10.1074/jbc.M112.425975

      2012
      • Journal Article
        Hyperthermia: from diagnostic and treatments to new discoveries.
        [Romero-Suarez, S, Mo, C, Touchberry, C, Lara, N, Baker, K, Craig, R, Brotto, L, Andresen, J, Wacker, M, Kaja, S, Abreu, E, Dillmann, W, Mestril, R, Brotto, M, Nosek, T]. 6(3), 172-83. DOI: http://dx.doi.org/10.2174/1872208311206030172
      • Journal Article
        Hyperthermia: from diagnostic and treatments to new discoveries.
        [Romero-Suarez, S, Mo, Chenglin, Touchberry, C, Lara, N, Baker, K, Craig, R, Brotto, L, Andresen, J, Wacker, M, Kaja, S, Abreu, E, Dillmann, W, Mestril, R, Brotto, Marco, Nosek, T]. 6(3), 172-83. DOI: http://dx.doi.org/10.2174/1872208311206030172
      • Journal Article
        Jatropha curcas: from biodiesel generation to medicinal applications.
        [Paulillo, LC, Mo, C, Isaacson, J, Lessa, L, Lopes, E, Romero-Suarez, S, Brotto, L, Abreu, E, Gutheil, W, Brotto, M]. 6(3), 192-9. DOI: http://dx.doi.org/10.2174/1872208311206030192
      • Journal Article
        Jatropha curcas: from biodiesel generation to medicinal applications.
        [Paulillo, LC, Mo, Chenglin, Isaacson, J, Lessa, L, Lopes, E, Romero-Suarez, S, Brotto, L, Abreu, E, Gutheil, W, Brotto, Marco]. 6(3), 192-9. DOI: http://dx.doi.org/10.2174/1872208311206030192
      • Journal Article
        Prostaglandin E2: from clinical applications to its potential role in bone- muscle crosstalk and myogenic differentiation.
        [Mo, C, Romero-Suarez, S, Bonewald, L, Johnson, M, Brotto, M]. 6(3), 223-9. DOI: http://dx.doi.org/10.2174/1872208311206030223
      • Journal Article
        Prostaglandin E2: from clinical applications to its potential role in bone- muscle crosstalk and myogenic differentiation.
        [Mo, Chenglin, Romero-Suarez, S, Bonewald, L, Johnson, M, Brotto, Marco]. 6(3), 223-9. DOI: http://dx.doi.org/10.2174/1872208311206030223
      • Journal Article
        Ex vivo assessment of contractility, fatigability and alternans in isolated skeletal muscles.
        [Park, KH, Brotto, L, Lehoang, O, Brotto, M, Ma, J, Zhao, X].(69), e4198. DOI: http://dx.doi.org/10.3791/4198
      • Journal Article
        Ex vivo assessment of contractility, fatigability and alternans in isolated skeletal muscles.
        [Park, Kyungseo, Brotto, L, Lehoang, O, Brotto, Marco, Ma, J, Zhao, X].(69), e4198. DOI: http://dx.doi.org/10.3791/4198
      • Journal Article
        Application of the M Technique in hospitalized very preterm infants: a feasibility study.
        [Smith, JR, Raney, M, Conner, S, Coffelt, P, McGrath, J, Brotto, M, Inder, T]. 12 Suppl 5, S10-7. DOI: http://dx.doi.org/10.1097/ANC.0b013e31826743ea
      • Journal Article
        Application of the M Technique in hospitalized very preterm infants: a feasibility study.
        [Smith, Jeremy, Raney, M, Conner, S, Coffelt, P, McGrath, J, Brotto, Marco, Inder, T]. 12 Suppl 5, S10-7. DOI: http://dx.doi.org/10.1097/ANC.0b013e31826743ea
      • Journal Article
        Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin.
        [Jähn, K, Lara-Castillo, N, Brotto, L, Mo, CL, Johnson, ML, Brotto, M, Bonewald, LF]. 24, 197-209; discussion 209-10. DOI: http://dx.doi.org/10.22203/ecm.v024a14
      • Journal Article
        Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin.
        [Jähn, K, Lara-Castillo, N, Brotto, L, Mo, Chenglin, Johnson, ML, Brotto, Marco, Bonewald, LF]. 24, 197-209; discussion 209-10. DOI: http://dx.doi.org/10.22203/ecm.v024a14
      • Journal Article
        Electric ventilation: indications for and technical aspects of diaphragm pacing stimulation surgical implantation.
        [Tedde, ML, Onders, RP, Teixeira, MJ, Lage, SG, Ballester, G, Brotto, MW, Okumura, EM, Jatene, FB]. 38(5), 566-72. DOI: http://dx.doi.org/10.1590/s1806-37132012000500005
      • Journal Article
        Electric ventilation: indications for and technical aspects of diaphragm pacing stimulation surgical implantation.
        [Tedde, ML, Onders, RP, Teixeira, MJ, Lage, SG, Ballester, G, Brotto, Marco, Okumura, EM, Jatene, FB]. 38(5), 566-72.
      • Journal Article
        Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
        [Haldar, SM, Jeyaraj, D, Anand, P, Zhu, H, Lu, Y, Prosdocimo, DA, Eapen, B, Kawanami, D, Okutsu, M, Brotto, L, Fujioka, H, Kerner, J, Rosca, MG, McGuinness, OP, Snow, RJ, Russell, AP, Gerber, AN, Bai, X, Yan, Z, Nosek, TM, Brotto, M, Hoppel, CL, Jain, MK]. 109(17), 6739-44. DOI: http://dx.doi.org/10.1073/pnas.1121060109
      • Journal Article
        Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
        [Haldar, SM, Jeyaraj, D, Anand, P, Zhu, H, Lu, Y, Prosdocimo, DA, Eapen, B, Kawanami, D, Okutsu, M, Brotto, L, Fujioka, H, Kerner, J, Rosca, MG, McGuinness, OP, Snow, RJ, Russell, AP, Gerber, AN, Bai, X, Yan, Z, Nosek, TM, Brotto, Marco, Hoppel, CL, Jain, MK]. 109(17), 6739-44. DOI: http://dx.doi.org/10.1073/pnas.1121060109
      • Journal Article
        Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report.
        [de Paiva, AR, Castro, LH, Rodrigues, Jr, W, Passarelli, V, Jorge, CL, Brotto, Marco, Hirata, MT, Marchiori, PE]. Journal of the Neurological Sciences. 315(1-2), 172-5. DOI: http://dx.doi.org/10.1016/j.jns.2011.11.015
      • Journal Article
        Fluorescence-based measurement of store-operated calcium entry in live cells: from cultured cancer cell to skeletal muscle fiber.
        [Pan, Z, Zhao, X, Brotto, M].(60), DOI: http://dx.doi.org/10.3791/3415
      • Journal Article
        Fluorescence-based measurement of store-operated calcium entry in live cells: from cultured cancer cell to skeletal muscle fiber.
        [Pan, Zui, Zhao, X, Brotto, Marco].(60), DOI: http://dx.doi.org/10.3791/3415

      2011
      • Journal Article
        Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium.
        [Touchberry, CD, Elmore, CJ, Nguyen, TM, Andresen, JJ, Zhao, X, Orange, M, Weisleder, N, Brotto, M, Claycomb, WC, Wacker, MJ]. Biochemical and Biophysical Research Communications. 416(1-2), 45-50. DOI: http://dx.doi.org/10.1016/j.bbrc.2011.10.133
      • Journal Article
        Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium.
        [Touchberry, CD, Elmore, CJ, Nguyen, TM, Andresen, JJ, Zhao, X, Orange, M, Weisleder, N, Brotto, Marco, Claycomb, WC, Wacker, MJ]. Biochemical and Biophysical Research Communications. 416(1-2), 45-50. DOI: http://dx.doi.org/10.1016/j.bbrc.2011.10.133
      • Journal Article
        Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.
        [Silswal, N, Parelkar, NK, Wacker, MJ, Brotto, M, Andresen, J]. American Journal of Physiology. Heart and Circulatory Physiology. 300(6), H2016-26. DOI: http://dx.doi.org/10.1152/ajpheart.01011.2010
      • Journal Article
        Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.
        [Silswal, N, Parelkar, NK, Wacker, MJ, Brotto, Marco, Andresen, J]. American Journal of Physiology. Heart and Circulatory Physiology. 300(6), H2016-26. DOI: http://dx.doi.org/10.1152/ajpheart.01011.2010
      • Journal Article
        Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
        [Thornton, AM, Zhao, X, Weisleder, N, Brotto, LS, Bougoin, S, Nosek, TM, Reid, M, Hardin, B, Pan, Z, Ma, J, Parness, J, Brotto, M]. Aging. 3(6), 621-34. DOI: http://dx.doi.org/10.18632/aging.100335
      • Journal Article
        Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
        [Thornton, AM, Zhao, X, Weisleder, N, Brotto, LS, Bougoin, S, Nosek, TM, Reid, MaryBeth, Hardin, B, Pan, Zui, Ma, J, Parness, J, Brotto, Marco]. Aging. 3(6), 621-34. DOI: http://dx.doi.org/10.18632/aging.100335
      • Journal Article
        PinhãO-Manso: A Native Jatropha Curcas from Brazil Protects Muscle Cells from Ethanol Toxicity and Improves Muscle Function
        [Brotto, Leticia, Paulillo, Luis, Lopes, Edjacy, Mo, Chenglin, Isaacson, Janalee, Carneiro, Pedro, Lessa, Luciene, Romero-Suarez, Sandra, Abreu, Eduardo, Brotto, Marco]. Biophysical Journal. 100(3), 288a. "Elsevier BV". DOI: http://dx.doi.org/10.1016/j.bpj.2010.12.1777
        http://dx.doi.org/10.1016/j.bpj.2010.12.1777
      • Journal Article
        Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
        [Tjondrokoesoemo, A, Park, KH, Ferrante, C, Komazaki, S, Lesniak, S, Brotto, M, Ko, JK, Zhou, J, Weisleder, N, Ma, J]. PLoS One. 6(9), e25740. DOI: http://dx.doi.org/10.1371/journal.pone.0025740
      • Journal Article
        Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
        [Tjondrokoesoemo, A, Park, Kyungseo, Ferrante, C, Komazaki, S, Lesniak, S, Brotto, Marco, Ko, JK, Zhou, Jingsong, Weisleder, N, Ma, J]. PLoS One. 6(9), e25740. DOI: http://dx.doi.org/10.1371/journal.pone.0025740

      2010
      • Journal Article
        Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor.
        [Touchberry, CD, Bales, IK, Stone, JK, Rohrberg, TJ, Parelkar, NK, Nguyen, T, Fuentes, O, Liu, X, Qu, CK, Andresen, JJ, Valdivia, HH, Brotto, M, Wacker, MJ]. The Journal of Biological Chemistry. 285(51), 40312-21. DOI: http://dx.doi.org/10.1074/jbc.M110.179689
      • Journal Article
        Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor.
        [Touchberry, CD, Bales, IK, Stone, JK, Rohrberg, TJ, Parelkar, NK, Nguyen, T, Fuentes, O, Liu, Xia, Qu, CK, Andresen, JJ, Valdivia, HH, Brotto, Marco, Wacker, MJ]. The Journal of Biological Chemistry. 285(51), 40312-21. DOI: http://dx.doi.org/10.1074/jbc.M110.179689
      • Journal Article
        Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.
        [Zhao, X, Yamazaki, D, Park, KH, Komazaki, S, Tjondrokoesoemo, A, Nishi, M, Lin, P, Hirata, Y, Brotto, M, Takeshima, H, Ma, J]. The Journal of Biological Chemistry. 285(48), 37370-6. DOI: http://dx.doi.org/10.1074/jbc.M110.170084
      • Journal Article
        Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.
        [Zhao, X, Yamazaki, D, Park, Kyungseo, Komazaki, S, Tjondrokoesoemo, A, Nishi, M, Lin, P, Hirata, Y, Brotto, Marco, Takeshima, H, Ma, J]. The Journal of Biological Chemistry. 285(48), 37370-6. DOI: http://dx.doi.org/10.1074/jbc.M110.170084
      • Journal Article
        Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.
        [Romero-Suarez, S, Shen, J, Brotto, L, Hall, T, Mo, C, Valdivia, HH, Andresen, J, Wacker, M, Nosek, TM, Qu, CK, Brotto, M]. Aging. 2(8), 504-13. DOI: http://dx.doi.org/10.18632/aging.100190
      • Journal Article
        Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.
        [Romero-Suarez, S, Shen, J, Brotto, L, Hall, ThomasW, Mo, Chenglin, Valdivia, HH, Andresen, J, Wacker, M, Nosek, TM, Qu, CK, Brotto, Marco]. Aging. 2(8), 504-13. DOI: http://dx.doi.org/10.18632/aging.100190
      • Journal Article
        Peripheral neuropathy in patients with primary antiphospholipid (Hughes') syndrome.
        [Santos, MS, de Carvalho, JF, Brotto, Marco, Bonfa, E, Rocha, FA]. 19(5), 583-90. DOI: http://dx.doi.org/10.1177/0961203309354541
      • Journal Article
        Temporal adaptive changes in contractility and fatigability of diaphragm muscles from streptozotocin-diabetic rats.
        [Brotto, M, Brotto, L, Jin, JP, Nosek, TM, Romani, A]. 2010, 931903. DOI: http://dx.doi.org/10.1155/2010/931903
      • Journal Article
        Temporal adaptive changes in contractility and fatigability of diaphragm muscles from streptozotocin-diabetic rats.
        [Brotto, Marco, Brotto, L, Jin, JP, Nosek, TM, Romani, A]. 2010, 931903. DOI: http://dx.doi.org/10.1155/2010/931903

      2009
      • Journal Article
        Inhibition of thromboxane A2-induced arrhythmias and intracellular calcium changes in cardiac myocytes by blockade of the inositol trisphosphate pathway.
        [Wacker, MJ, Kosloski, LM, Gilbert, WJ, Touchberry, CD, Moore, DS, Kelly, JK, Brotto, M, Orr, JA]. 331(3), 917-24. DOI: http://dx.doi.org/10.1124/jpet.109.157677
      • Journal Article
        Inhibition of thromboxane A2-induced arrhythmias and intracellular calcium changes in cardiac myocytes by blockade of the inositol trisphosphate pathway.
        [Wacker, MJ, Kosloski, LM, Gilbert, WJ, Touchberry, CD, Moore, DS, Kelly, JK, Brotto, Marco, Orr, JA]. 331(3), 917-24. DOI: http://dx.doi.org/10.1124/jpet.109.157677
      • Journal Article
        Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.
        [Shen, J, Yu, WM, Brotto, M, Scherman, JA, Guo, C, Stoddard, C, Nosek, TM, Valdivia, HH, Qu, CK]. Nature Cell Biology. 11(6), 769-76. DOI: http://dx.doi.org/10.1038/ncb1884
      • Journal Article
        Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.
        [Shen, J, Yu, WM, Brotto, Marco, Scherman, JA, Guo, C, Stoddard, C, Nosek, TM, Valdivia, HH, Qu, CK]. Nature Cell Biology. 11(6), 769-76. DOI: http://dx.doi.org/10.1038/ncb1884
      • Journal Article
        MG53 nucleates assembly of cell membrane repair machinery.
        [Cai, C, Masumiya, H, Weisleder, N, Matsuda, N, Nishi, M, Hwang, M, Ko, JK, Lin, P, Thornton, A, Zhao, X, Pan, Z, Komazaki, S, Brotto, M, Takeshima, H, Ma, J]. Nature Cell Biology. 11(1), 56-64. DOI: http://dx.doi.org/10.1038/ncb1812
      • Journal Article
        MG53 nucleates assembly of cell membrane repair machinery.
        [Cai, C, Masumiya, H, Weisleder, N, Matsuda, N, Nishi, M, Hwang, M, Ko, JK, Lin, P, Thornton, A, Zhao, X, Pan, Zui, Komazaki, S, Brotto, Marco, Takeshima, H, Ma, J]. Nature Cell Biology. 11(1), 56-64. DOI: http://dx.doi.org/10.1038/ncb1812

      2008
      2007
      2006
      • Journal Article
        Occurrence of nervous system involvement in SIRS.
        [Marchiori, PE, Lino, AM, Hirata, MT, Carvalho, NB, Brotto, Marco, Scaff, M]. Journal of the Neurological Sciences. 250(1-2), 147-52. DOI: http://dx.doi.org/10.1016/j.jns.2006.08.015
      • Journal Article
        Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.
        [Zhao, X, Weisleder, N, Han, X, Pan, Z, Parness, J, Brotto, M, Ma, J]. The Journal of Biological Chemistry. 281(44), 33477-86. DOI: http://dx.doi.org/10.1074/jbc.M602306200
      • Journal Article
        Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.
        [Zhao, X, Weisleder, N, Han, X, Pan, Zui, Parness, J, Brotto, Marco, Ma, J]. The Journal of Biological Chemistry. 281(44), 33477-86. DOI: http://dx.doi.org/10.1074/jbc.M602306200
      • Journal Article
        Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.
        [Weisleder, N, Brotto, M, Komazaki, S, Pan, Z, Zhao, X, Nosek, T, Parness, J, Takeshima, H, Ma, J]. The Journal of Cell Biology. 174(5), 639-45. DOI: http://dx.doi.org/10.1083/jcb.200604166
      • Journal Article
        Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.
        [Weisleder, N, Brotto, Marco, Komazaki, S, Pan, Zui, Zhao, X, Nosek, T, Parness, J, Takeshima, H, Ma, J]. The Journal of Cell Biology. 174(5), 639-45. DOI: http://dx.doi.org/10.1083/jcb.200604166
      • Journal Article
        Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes.
        [Hirata, Y, Brotto, M, Weisleder, N, Chu, Y, Lin, P, Zhao, X, Thornton, A, Komazaki, S, Takeshima, H, Ma, J, Pan, Z]. Biophysical Journal. 90(12), 4418-27. DOI: http://dx.doi.org/10.1529/biophysj.105.076570
      • Journal Article
        Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes.
        [Hirata, Y, Brotto, Marco, Weisleder, N, Chu, Y, Lin, P, Zhao, X, Thornton, A, Komazaki, S, Takeshima, H, Ma, J, Pan, Zui]. Biophysical Journal. 90(12), 4418-27. DOI: http://dx.doi.org/10.1529/biophysj.105.076570
      • Journal Article
        Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility.
        [Brotto, MA, Biesiadecki, BJ, Brotto, LS, Nosek, TM, Jin, JP]. American Journal of Physiology. Cell Physiology. 290(2), C567-76. DOI: http://dx.doi.org/10.1152/ajpcell.00422.2005
      • Journal Article
        Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility.
        [Brotto, Marco, Biesiadecki, BJ, Brotto, LS, Nosek, TM, Jin, JP]. American Journal of Physiology. Cell Physiology. 290(2), C567-76. DOI: http://dx.doi.org/10.1152/ajpcell.00422.2005

      2005
      • Journal Article
        Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice.
        [Zhao, X, Yoshida, M, Brotto, L, Takeshima, H, Weisleder, N, Hirata, Y, Nosek, TM, Ma, J, Brotto, M]. Physiological Genomics. 23(1), 72-8. DOI: http://dx.doi.org/10.1152/physiolgenomics.00020.2005
      • Journal Article
        Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice.
        [Zhao, X, Yoshida, M, Brotto, L, Takeshima, H, Weisleder, N, Hirata, Y, Nosek, TM, Ma, J, Brotto, Marco]. Physiological Genomics. 23(1), 72-8. DOI: http://dx.doi.org/10.1152/physiolgenomics.00020.2005
      • Journal Article
        Functional and biochemical modifications in skeletal muscles from malarial mice.
        [Brotto, MA, Marrelli, MT, Brotto, LS, Jacobs-Lorena, M, Nosek, TM]. Experimental Physiology. 90(3), 417-25. DOI: http://dx.doi.org/10.1113/expphysiol.2004.028316
      • Journal Article
        Functional and biochemical modifications in skeletal muscles from malarial mice.
        [Brotto, Marco, Marrelli, MT, Brotto, LS, Jacobs-Lorena, M, Nosek, TM]. Experimental Physiology. 90(3), 417-25. DOI: http://dx.doi.org/10.1113/expphysiol.2004.028316
      • Journal Article
        Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle.
        [Wang, X, Weisleder, N, Collet, C, Zhou, J, Chu, Y, Hirata, Y, Zhao, X, Pan, Z, Brotto, M, Cheng, H, Ma, J]. Nature Cell Biology. 7(5), 525-30. DOI: http://dx.doi.org/10.1038/ncb1254
      • Journal Article
        Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle.
        [Wang, X, Weisleder, N, Collet, C, Zhou, Jingsong, Chu, Y, Hirata, Y, Zhao, X, Pan, Zui, Brotto, Marco, Cheng, H, Ma, J]. Nature Cell Biology. 7(5), 525-30. DOI: http://dx.doi.org/10.1038/ncb1254

      2004
      • Journal Article
        Troponin T isoforms alter the tolerance of transgenic mouse cardiac muscle to acidosis.
        [Nosek, TM, Brotto, MA, Jin, JP]. Archives of Biochemistry and Biophysics. 430(2), 178-84. DOI: http://dx.doi.org/10.1016/j.abb.2004.07.014
      • Journal Article
        Troponin T isoforms alter the tolerance of transgenic mouse cardiac muscle to acidosis.
        [Nosek, TM, Brotto, Marco, Jin, JP]. Archives of Biochemistry and Biophysics. 430(2), 178-84. DOI: http://dx.doi.org/10.1016/j.abb.2004.07.014
      • Journal Article
        Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice.
        [Brotto, MA, Nagaraj, RY, Brotto, LS, Takeshima, H, Ma, JJ, Nosek, TM]. Cell Research. 14(5), 373-8. DOI: http://dx.doi.org/10.1038/sj.cr.7290237
      • Journal Article
        Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice.
        [Brotto, Marco, Nagaraj, RY, Brotto, LS, Takeshima, H, Ma, JJ, Nosek, TM]. Cell Research. 14(5), 373-8. DOI: http://dx.doi.org/10.1038/sj.cr.7290237
      • Journal Article
        A novel stop codon mutation in the PMP22 gene associated with a variable phenotype.
        [Abe, KT, Lino, AM, Hirata, MT, Pavanello, RC, Brotto, Marco, Marchiori, PE, Zatz, M]. 14(5), 313-20. DOI: http://dx.doi.org/10.1016/j.nmd.2004.01.007
      • Journal Article
        Granular cell tumor of the intrapancreatic common bile duct: one case report and review of the literature.
        [Altavilla, G, Brotto, Marco, Busatto, G, Boccù, C, Ragni, L]. 28(3), 171-6. DOI: http://dx.doi.org/10.1080/01913120490475752
      • Journal Article
        Monophasic synovial sarcoma of hypopharynx: case report and review of the literature.
        [Artico, R, Bison, E, Brotto, Marco]. 24(1), 33-6.

      2003
      • Journal Article
        Trifluoroacetylated proteins in liver and plasma of guinea pigs treated with HCFC-123 and halothane.
        [Bortolato, S, Zanovello, A, Rugge, M, Brotto, Marco, Marini, S, Gervasi, PG, Manno, M]. 144(1), 35-47. DOI: http://dx.doi.org/10.1016/s0378-4274(03)00228-5
      • Journal Article
        Truncation by Glu180 nonsense mutation results in complete loss of slow skeletal muscle troponin T in a lethal nemaline myopathy.
        [Jin, JP, Brotto, MA, Hossain, MM, Huang, QQ, Brotto, LS, Nosek, TM, Morton, DH, Crawford, TO]. The Journal of Biological Chemistry. 278(28), 26159-65. DOI: http://dx.doi.org/10.1074/jbc.M303469200
      • Journal Article
        Truncation by Glu180 nonsense mutation results in complete loss of slow skeletal muscle troponin T in a lethal nemaline myopathy.
        [Jin, JP, Brotto, Marco, Hossain, MM, Huang, QQ, Brotto, LS, Nosek, TM, Morton, DH, Crawford, TO]. The Journal of Biological Chemistry. 278(28), 26159-65. DOI: http://dx.doi.org/10.1074/jbc.M303469200

      2002
      • Journal Article
        [Diagnosis of schistosomiasis of the spinal cord: contribution of magnetic resonance imaging and electroneuromyography].
        [Peregrino, AJ, Puglia, PM, Bacheschi, LA, Hirata, MT, Brotto, Marco, Nobrega, JP, Scaff, M]. 60(3-A), 597-602.
      • Journal Article
        Distinct patterns of p27/KIP 1 gene expression in hepatoblastoma and prognostic implications with correlation before and after chemotherapy.
        [Brotto, Marco, Finegold, MJ]. 33(2), 198-205. DOI: http://dx.doi.org/10.1053/hupa.2002.31294
      • Journal Article
        Influence of ageing on the fatigability of isolated mouse skeletal muscles from mature and aged mice.
        [Brotto, MA, Nosek, TM, Kolbeck, RC]. Experimental Physiology. 87(1), 77-82. DOI: http://dx.doi.org/10.1113/eph8702224
      • Journal Article
        Influence of ageing on the fatigability of isolated mouse skeletal muscles from mature and aged mice.
        [Brotto, Marco, Nosek, TM, Kolbeck, RC]. Experimental Physiology. 87(1), 77-82. DOI: http://dx.doi.org/10.1113/eph8702224

      2001
      2000
      • Journal Article
        Functional properties of skeletal muscle from transgenic animals with upregulated heat shock protein 70.
        [Nosek, TM, Brotto, MA, Essig, DA, Mestril, R, Conover, RC, Dillmann, WH, Kolbeck, RC]. Physiological Genomics. 4(1), 25-33. DOI: http://dx.doi.org/10.1152/physiolgenomics.2000.4.1.25
      • Journal Article
        Functional properties of skeletal muscle from transgenic animals with upregulated heat shock protein 70.
        [Nosek, TM, Brotto, Marco, Essig, DA, Mestril, R, Conover, RC, Dillmann, WH, Kolbeck, RC]. Physiological Genomics. 4(1), 25-33. DOI: http://dx.doi.org/10.1152/physiolgenomics.2000.4.1.25
      • Journal Article
        Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene.
        [Nagaraj, RY, Nosek, CM, Brotto, MA, Nishi, M, Takeshima, H, Nosek, TM, Ma, J]. Physiological Genomics. 4(1), 43-9. DOI: http://dx.doi.org/10.1152/physiolgenomics.2000.4.1.43
      • Journal Article
        Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene.
        [Nagaraj, RY, Nosek, CM, Brotto, Marco, Nishi, M, Takeshima, H, Nosek, TM, Ma, J]. Physiological Genomics. 4(1), 43-9. DOI: http://dx.doi.org/10.1152/physiolgenomics.2000.4.1.43
      • Journal Article
        Hypoxia and fatigue-induced modification of function and proteins in intact and skinned murine diaphragm muscle.
        [Brotto, MA, Andreatta-van Leyen, S, Nosek, CM, Brotto, LS, Nosek, TM]. 440(5), 727-34. DOI: http://dx.doi.org/10.1007/s004240000327
      • Journal Article
        Hypoxia and fatigue-induced modification of function and proteins in intact and skinned murine diaphragm muscle.
        [Brotto, Marco, Andreatta-van Leyen, S, Nosek, CM, Brotto, LS, Nosek, TM]. 440(5), 727-34. DOI: http://dx.doi.org/10.1007/s004240000327

      1999
      • Journal Article
        Bradykinin receptor localization and cell signaling pathways used by bradykinin in the regulation of gonadotropin-releasing hormone secretion.
        [Shi, B, Bhat, G, Mahesh, VB, Brotto, M, Nosek, TM, Brann, DW]. Endocrinology. 140(10), 4669-76. DOI: http://dx.doi.org/10.1210/endo.140.10.7069
      • Journal Article
        Bradykinin receptor localization and cell signaling pathways used by bradykinin in the regulation of gonadotropin-releasing hormone secretion.
        [Shi, B, Bhat, G, Mahesh, VB, Brotto, Marco, Nosek, TM, Brann, DW]. Endocrinology. 140(10), 4669-76. DOI: http://dx.doi.org/10.1210/endo.140.10.7069

      1998
      • Journal Article
        Aggressive angiomyxoma of the vulva: expression of estroprogestinic receptors and follow-up.
        [De Salvia, D, Fais, GF, Lauri, F, Brotto, Marco, Petrillo, G, Salmaso, R]. 25(4), 141-3.
      • Journal Article
        Rectosigmoid endometriosis: diagnosis and surgical management.
        [Azzena, A, Litta, P, Ferrara, A, Perin, D, Brotto, Marco, Chiarelli, S, Sandei, F]. 25(3), 94-6.

      1997
      • Journal Article
        Neural crest is involved in development of abnormal myocardial function.
        [Conway, SJ, Godt, RE, Hatcher, CJ, Leatherbury, L, Zolotouchnikov, VV, Brotto, MA, Copp, AJ, Kirby, ML, Creazzo, TL]. Journal of Molecular and Cellular Cardiology. 29(10), 2675-85. DOI: http://dx.doi.org/10.1006/jmcc.1997.0499
      • Journal Article
        Neural crest is involved in development of abnormal myocardial function.
        [Conway, SJ, Godt, RE, Hatcher, CJ, Leatherbury, L, Zolotouchnikov, VV, Brotto, Marco, Copp, AJ, Kirby, Maggie, Creazzo, TL]. Journal of Molecular and Cellular Cardiology. 29(10), 2675-85. DOI: http://dx.doi.org/10.1006/jmcc.1997.0499
      • Journal Article
        Effect of cardiac neural crest ablation on contractile force and calcium uptake and release in chick heart.
        [Nosek, TM, Fogaça, RT, Hatcher, CJ, Brotto, MA, Godt, RE]. 273(3 Pt 2), H1464-71. DOI: http://dx.doi.org/10.1152/ajpheart.1997.273.3.H1464
      • Journal Article
        Effect of cardiac neural crest ablation on contractile force and calcium uptake and release in chick heart.
        [Nosek, TM, Fogaça, RT, Hatcher, CJ, Brotto, Marco, Godt, RE]. 273(3 Pt 2), H1464-71. DOI: http://dx.doi.org/10.1152/ajpheart.1997.273.3.H1464

      1996
      1995
      • Journal Article
        Approximating the isometric force-calcium relation of intact frog muscle using skinned fibers.
        [Maughan, DW, Molloy, JE, Brotto, MA, Godt, RE]. Biophysical Journal. 69(4), 1484-90. DOI: http://dx.doi.org/10.1016/S0006-3495(95)80019-6
      • Journal Article
        Approximating the isometric force-calcium relation of intact frog muscle using skinned fibers.
        [Maughan, DW, Molloy, JE, Brotto, Marco, Godt, RE]. Biophysical Journal. 69(4), 1484-90. DOI: http://dx.doi.org/10.1016/S0006-3495(95)80019-6
      • Journal Article
        Autosomal recessive nondystrophic myotonia. Report of a case with unusual clinical course.
        [Reed, UC, Marie, SK, Brotto, Marco, Martinez, CA, Marchiori, PE, Diament, A, Levy, JA]. 53(1), 114-7. DOI: http://dx.doi.org/10.1590/s0004-282x1995000100017
      • Journal Article
        Hyperekplexia, a cause of neonatal apnea: a case report.
        [Gherpelli, JL, Nogueira, Jr, AR, Troster, EJ, Deutsch, AD, Leoné, CR, Brotto, Marco, Diament, A, Ramos, JL]. Brain & Development. 17(2), 114-6. DOI: http://dx.doi.org/10.1016/0387-7604(94)00113-c
      • Journal Article
        The effect of 2,3-butanedione 2-monoxime (BDM) on ventricular trabeculae from the avian heart.
        [Brotto, MA, Fogaça, RT, Creazzo, TL, Godt, RE, Nosek, TM]. Journal of Muscle Research and Cell Motility. 16(1), 1-10. DOI: http://dx.doi.org/10.1007/BF00125305
      • Journal Article
        The effect of 2,3-butanedione 2-monoxime (BDM) on ventricular trabeculae from the avian heart.
        [Brotto, Marco, Fogaça, RT, Creazzo, TL, Godt, RE, Nosek, TM]. Journal of Muscle Research and Cell Motility. 16(1), 1-10. DOI: http://dx.doi.org/10.1007/bf00125305

      2014
      • Conference Proceeding
        Simplified Closed Form Numerical Approaches to Predict Natural Rubber Behavior under Sulfur Curing in Standard Rheometer Tests
        Proceedings of the 4th International Conference on Simulation and Modeling Methodologies, Technologies and Applications
        [Brotto, Marco, Milani, Gabriele, Milani, Federico]. "SCITEPRESS - Science and Technology Publications". DOI: http://dx.doi.org/10.5220/0005013401410147
        http://dx.doi.org/10.5220/0005013401410147

      2013
      • Conference Proceeding
        Characterization of myogenesis in C2C12 myoblasts using Flow Cytometry
        [Brotto, Marco, Yang, Z, Mo, C, Isaacson, J, Romero-Suarez, S, Vallejo, J, Alsousi, A, Wetmore, L]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
        https://www.fasebj.org/doi/abs/10.1096/fasebj.27.1_supplement.1152.17
      • Conference Proceeding
        DELETION OF MBTPS1 IN BONE LEADS TO ENHANCEMENT OF MUSCLE MASS AND FUNCTION IN MATURE MICE
        [Brotto, Marco, Gorski, J, Huffman, NT, Breggia, A, Rosen, CJ, Chittur, SC, Stern, A, Dallas, M, Seidah, NG, Brotto, L, Bonewald, L]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
        https://www.fasebj.org/doi/abs/10.1096/fasebj.27.1_supplement.942.3
      • Conference Proceeding
        METTL21C: From GWAS to in vitro function in skeletal muscle cells
        [Brotto, Marco, Huang, J, Hsu, YH, Mo, C, Abreu, E, Karasik, D]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Conference Proceeding
        Prostaglandin E2 signaling plays an important role in the regulation of the cell cycle progression in C2C12 myoblasts
        [Brotto, Marco, Mo, C, Vallejo, J, Isaacson, J, Yang, Z, Wetmore, L, Allen, T, Igwe, O]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
        https://www.fasebj.org/doi/abs/10.1096/fasebj.27.1_supplement.1152.18

      2012
      2011
      • Conference Proceeding
        Impaired vascular function in female Dentin matrix protein 1 null mice
        [Silswal, N, Wacker, MJ, Brotto, Marco, Bonewald, L, Andresen, J]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.25.1_supplement.1026.34
      • Conference Proceeding
        Skeletal Muscles Maintain Osteocyte Viability
        [Brotto, Marco, Jahn, K, Nuria, L, Mo, C, Romero-Suarez, S, Brotto, LS, Johnson, M, Bonewald, L]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.25.1_supplement.1059.18
      • Conference Proceeding
        The HL-1 cardiomyocyte cell line exhibits store-operated calcium entry
        [Brotto, Marco, Touchberry, C, Elmore, C, Nguyen, T, Andresen, J, Zhao , X, Orange, M, Weisleder, N, Claycomb, W, Wacker, M]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.25.1_supplement.1112.11

      2010
      • Conference Proceeding
        Heat-Shock Treatment Induces Hypertrophy in C2C12 Muscle Cells
        [Brotto, Marco, Hall, T, Touchberry, C, Craig, R, Brotto, L, Loghry, M, Andresen, J, Wacker, M]. Biophysical Journal. DOI: http://dx.doi.org/10.1016/j.bpj.2009.12.824
      • Conference Proceeding
        Evidence for pathophysiological crosstalk between bones, cardiac, skeletal and smooth muscles
        [Brotto, Marco, Brotto, LS, Silswal, N, Touchberry, C, Parelkar, N, Craig, R, Hall, T, Loghry, M, Shen, J, Qu, CK, Bonewald, L, Johnson, M, Wacker, M, Andresen, J]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.24.1_supplement.1046.8
      • Conference Proceeding
        Mild Heat Shock Promotes Hypertrophy in Cardiac, Skeletal and Smooth Muscle Cells
        [Brotto, Marco, Hall, T, Craig, R, Touchberry, C, Silswal, N, Elmore, C, Baker, K, Andresen, J, Wacker, M]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.24.1_supplement.1047.3
      • Conference Proceeding
        MIP/MTMR14 is implicated in skeletal muscle aging
        [Brotto, Marco, Brotto, Leticia, Craig, Robin, Hall, Todd, Loghry, Michael, Valvida, Hector, Nosek, Thomas, Shen, J, Qu, CK]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.24.1_supplement.621.3
      • Conference Proceeding
        Phosphatidylinositol 3,5 bisphosphate increases contractility and intracellular calcium in cardiac muscle by directly activating the cardiac ryanodine receptor.
        [Touchberry, CD, Bales, IK, Brotto, Marco, Valdivia, HH, Wacker, MJ]. DOI: http://dx.doi.org/10.1096/fasebj.24.1_supplement.1048.3

      2009
      • Conference Proceeding
        Alterations in skeletal muscle contractile force following acute exposure to thromboxane A2.
        [Brotto, Marco, Touchberry, CD, Stone, JK, Brotto, LS, Wacker, MJ]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.23.1_supplement.600.5
      • Conference Proceeding
        Discovery and functional characterization of the novel muscle-specific inositol phosphatase MIP (MTMR14)
        [Brotto, Marco, Qu, C, Shen, J, Yu, WM, Guo, C, Stoddard, C, Nosek, TM]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.23.1_supplement.780.1
      • Conference Proceeding
        Effects of PI(3,5)P2 on the Skeletal Muscle Ryanodine Receptor
        [Brotto, Marco, Sherman , J, Nosek, T, Qu, CK, Valdivia, H]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Conference Proceeding
        Effects of PI(3,5)P2 on the Skeletal Muscle Ryanodine Receptor
        [Brotto, Marco, Sherman , JA, Nosek, TM, Qu, CK, Valvida, HH]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.23.1_supplement.780.3
      • Conference Proceeding
        Loss of muscle-specific inositol phosphatase (MIP) and increased phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) inhibit muscle contractility and produce a Brody’s disease phenotype
        [Brotto, Marco, Nosek, TM, Brotto, L, Cheng-Kui, KQ]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.23.1_supplement.780.2
      • Conference Proceeding
        The effects of phosphatidylinositol 3,5-bisphosphate on cardiac muscle
        [Wacker, MJ, Touchberry, CD, Rohrberg, TJ, Qu, CK, Brotto, Marco]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1096/fasebj.23.1_supplement.780.4

      2007
      • Conference Proceeding
        Compromised store-operated Ca entry (SOCE) in aged skeletal muscle
        [Brotto, Marco, Zhao, X, Thornton, A, Campbell, R, Oppong, Y, Weisleder , N, Ma, J]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. DOI: http://dx.doi.org/10.1111/j.1474-9726.2008.00408.x

      2018
      • Abstract
        Fibroblast Growth Factor 9 (FGF9) is Expressed in An Osteocyte-like “Mini-bone” Cell Line and Inhibits C2C12 Myogenesis via Overexpression of Myostatin
        [Brotto, Marco, Huang, J, Wang, K, McCormick, L, Brotto, L, Dallas, S]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Kvβ subunit interacts with NEDD4 leading to decreased mouse skeletal muscle size.
        [Tipparaju, S, Tur, J, Brotto, Marco, Chapalamadagu, K]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.

      2017
      • Abstract
        Extracellular Vesicle-Mediated Cell-Cell Communication in Bone and Potential Role in Muscle-Bone Crosstalk
        [Tiede-Lewis, L, Wang , K, McCormick, L, Lara, N, Keightley, A, Farina, N, Huang, J, Brotto, Marco, Lian, J, Bonewald, L, Dallas, S]. J Bone Miner Res.
      • Abstract
        Lack of a direct effect of FGF23 on skeletal muscle contractility, Ca2+ handling and development
        [Vallejo, J, Avin, K, Chen, N, Brotto, Marco, Wang, K, Touchberry, C, Dallas, S, Wacker, M]. J Bone Miner Res.
      • Abstract
        Long-Term Exercise Restores Key Lipid Mediators in Muscle
        [Brotto, Marco, Mo, C, Vallejo, J, Wang, Z, Bian, L, O’Connell, T, Bonewald, L, Wacker, M]. J Bone Miner Res.
      • Abstract
        Long-term physiologic exercise maintains the protective effects of muscle-secreted factors on osteocyte viability
        [Brotto, Marco, KITASE, Y, ZHAO, H, ROSSER, J, WACKER, M, VALLEJO, J, BONEWALD, L]. J Bone Miner Res.

      2016
      • Abstract
        A Metabolite of Contracted Muscle, β-aminoisobutyric Acid, BAIBA, Inhibits Trabecular Bone Loss by Hindlimb Unloading Potentially through Maintenance of Osteocyte Viability
        [Kitase, Y, Yi, J, Vallejo, J, Vemula, H, Gutheil, W, Brotto, Marco, Bonewald, L]. J Bone Miner Res.
      • Abstract
        Is Leptin an Age-related Paracrine\Autocrine Factor for Muscle?
        [Brotto, Marco, Gorski , JP]. J Bone Miner Res 31.
      • Abstract
        Prostaglandin E2 signaling through EP4 receptor interacts with Keap1/Nrf-2 pathway in myogenesis and aging
        [Brotto, Marco, Mo, C, Bonewald, L]. J Bone Miner Res 31.

      2015
      • Abstract
        FGF9 is highly expressed in an osteocyte-like “mini-bone” cell line and inhibits C2C12 myogenesis via overexpression of myostatin
        [Brotto, Marco, Choi, J, Robbles, D, Evans, S, Dallas, S]. J Bone Miner Res 30.
      • Abstract
        Indirect Effects of Factors from Contracted Muscle on Osteoblasts via Osteocytes
        [Brotto, Marco, Zhao, JP, Prideaux, M, Kitase, Y, Vallejo, J, Dallas, S, Bonewald, L]. J Bone Miner Res.
      • Abstract
        Cellular and Physiological Implications of Dietary Supplementation with Beta-Hydroxy-Beta-Methylbutyrate and Beta-Alanine in Late Middle-Aged Mice
        [Brotto, Marco, Vallejo, J, Spence, M, Cheng, AL, Brotto, L, Edens, N, Garvey, S]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Crosstalk between Bone and Muscle: Deletion of Mbtps1 in Bone Leads to Age-Dependent Increase in Muscle Size and Contractile Function
        [Gorski, J, Huffman, N, Seidah, N, Bonewald, L, Brotto, Marco]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Prostaglandin E2 Signaling via EP4 Receptor is Important for Cell Cycle Progression and the Regulation of Reactive Oxygen Species Production in Primary Myoblast
        [Brotto, Marco, Mo, C, Wetmore, L, Zhao, R, Bonewald, L]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Tendon Cells Demonstrate Store-Operated Calcium Entry Capacity and Differences in Calcium Signaling Through Aging
        [Johnson, K, Vallejo, J, Abreu, E, Brotto, Marco]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Wnt3a and Wnt1 Enhance Myogenesis of C2C12 Myoblasts – Potential Mechanisms of Osteocyte to Muscle Cell Signaling
        [Huang, J, Mo, C, Bonewald, L, Brotto, Marco]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Julian A. Vallejo Liubov V. Gushchina Sainath Kotha Narasimham Parinandi Noah Weisleder Marco Brotto Show all authors Open Archive1354-PosB305DOI:https://doi.org/10.1016/j.bpj.2014.11.1477 PlumX Metrics
        [Brotto, Marco, Vallejo, J, Gushchina, L, Kotha, S, Brotto, L, Parinandi, N, Weisleder, N]. BioProducts Business.

      2014
      • Abstract
        Bone-muscle crosstalk: more than mechanical (704.3)
        [Isaacson, J, Mo, C, Brotto, L, Huang, J, Spence, M, Vallejo, J, Abreu, E, Dallas, S, Johnson, M, Bonewald, L, Brotto, Marco]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Dysfunctional calcium homeostasis in aged mice primary tenocytes:a potential functional link to tendon disorders
        [Brotto, Marco, Vallejo, J, Spence, M, Brotto, L, Abreu, E]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Pinhão-manso (Jatropha curcas) demonstrates potent antibacterial properties in a rat model of third degree burns (1180.18)
        [Paulillo, L, de Sousa Lessa, G, Isaacson, J, Mo, C, Brotto, L, Abreu, E, Brotto, Marco, Gomes Mourão e Lima, J]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
      • Abstract
        Wnt3a potentiates myogenesis in C2C12 myoblasts through the modulation of intracellular calcium and activation of the β-catenin signaling pathway (1102.23)
        [Huang, J, Mo, C, Bonewald, L, Brotto, Marco]. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.

      2011
      • Abstract
        Pge2 Accelerates Myogenesis of C2c12 Myoblasts
        [Brotto, Marco, Mo, Romero-Suarez, S]. Biophysical Journal.

      2010
      • Abstract
        Knockdown of TRIC-B from tric-a-/-mice Alters Intracellular Ca2+ Signaling in Skeletal and Cardiac Muscles
        [Brotto, Marco, Park, K, Zhao, X, Yamazaki, D, Pitt, S, Tjondrokoesoemo, A, Komazaki, S, Ko, J, Lin, P]. Biophysical Journal.

      2009
      • Abstract
        MG53 Nucleates Assembly Of Cell Membrane Repair Machinery
        [Brotto, Marco, Cai, C, Masumiya, H, Weisleder, N, Matsuda, N, Nishi, M, Hwang, M, Ko, J, Lin, P]. Biophysical Journal.

      2006
      • Abstract
        Uncoupling Store-Operated Ca2+ Entry and Altered Ca2+ Release from Sarcoplasmic Reticulum through Silencing of Junctophilin Genes
        [Brotto, Marco, Hirata, Y, Weisleder, N, Chu, Y, Lin, P, Zhao, X, Thornton, A, Komazaki, S]. Biophysical Journal.

Presentations

    •  2012
      Brotto, Marco, "Invited Speaker ", San Diego, California. ( , 2012).
    • October  2012
      Brotto, Marco, "Bone-Muscle Interactions, American Society of Bone and Mineral Research (ASBMR)". (October 14, 2012).
    • September  2012
      Brotto, Marco, "Invited Speaker", University of Barcelona, Barcelona, Spain. (September 14, 2012).
    •  2010
      Brotto, Marco, "Invited Speaker at 5 Universities in the U.S and 2 in Brazil". ( , 2010).
    •  2010
      Brotto, Marco, "Invited Speaker at seven Universities in the U.S and 2 in Brazil". ( , 2010).
    •  2009
      Brotto, Marco, "During 2009 I was an Invited Speaker at 10 different Institutions in the US and Brazil. I also spoke at the Eli Lilly Research Campus in Indianapolis, IN.". ( , 2009).
    •  2008
      Brotto, Marco, "Featured Speaker", Kansas City Bone & Tooth Lecture, Schools of Dentistry and Medicine, University of Missouri-Kansas City. ( , 2008).
    • November  2008
      Brotto, Marco, "Speaker and Poster Presenter", New Orleans. (November 06, 2008).
    • October  2008
      Brotto, Marco, "Featured Speaker", Department of Physiology & Biophysics. (October 27, 2008).
    • October  2008
      Brotto, Marco, "Featured Speaker", Maceio, Alagoas. (October 05, 2008).
    • September  2008
      Brotto, Marco, "Featured Speaker", Department of Cell Biology, Piscataway, NJ. (September 29, 2008).
    • July  2008
      Brotto, Marco, "Featured Speaker". (July 01, 2008).
    • July  2008
      Brotto, Marco, "Featured Speaker", Department of Molecular Cardiology, Chicago, ILlinois. (July 01, 2008).
    • May  2007
      Brotto, Marco, "International Speaker and Featured Lecturer", International Conference on “Muscle and Exercise Physiology”, Jequie, Bahia, Brazil. (May 26, 2007).
    • February  2007
      Brotto, Marco, "“Muscle Fatigue and Aging: From Milieu to Genes”", UMKC Schools of Medicine and Nursing. (February 15, 2007).
    • November  2006
      Brotto, Marco, "“Novel Insights into Muscle Fatigue and Aging”", West Virginia Osteopathic School. (November 23, 2006).
    • October  2006
      Brotto, Marco, "Muscle Fatigue and Aging, A Tale of 2 Genes?", Irma-Lerma School of Pharmacy, Texas A&M. (October 15, 2006).
    • July  2006
      Brotto, Marco, "International Speaker and Lecturer", University of Sciences and Technology, Salvador, Bahia, Brazi. (July 02, 2006).
    • May  2006
      Brotto, Marco, "International Speaker and Lecturer", University of Sciences and Technology, Salvador, Bahia, Brazil. (May 29, 2006).
    •  2004
      Brotto, Marco, "Presenter". ( , 2004).
    •  2003
      Brotto, Marco, "Excitation Contraction Coupling", New London NH. ( , 2003).
    •  2003
      Brotto, Marco, "Speaker", APS Muscle BIO Group, San Diego, CA. ( , 2003).
    •  2002
      Brotto, Marco, "Speake", Muscle Fatigue Symposium, APS Muscle BIO Group, San Diego, CA. ( , 2002).
    •  2001
      Brotto, Marco, "Speaker", Muscle Fatigue Symposium, APS Muscle BIO Group, San Diego, CA. ( , 2001).
    •  2000
      Brotto, Marco, "Excitation Contraction Coupling", New London-NH. ( , 2000).
    •  1999
      Brotto, Marco, "Calcium Signaling", Henniker-NH. ( , 1999).
    •  1999
      Brotto, Marco, "Speaker at Faculty Departmental Seminar", Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA. ( , 1999).
    •  1998
      Brotto, Marco, "Speaker at Departmental Seminar", Physiology and Endocrinology Departmental Seminars. ( , 1998).
    •  1997
      Brotto, Marco, "Invited Speaker", The Heart Development Group, The Medical College of Georgia.. ( , 1997).
    •  1996
      Brotto, Marco, "Invited Speaker", The Heart Development Group, Medical College of Georgia. ( , 1996).

Students Supervised

    • Present
      Dissertation Committee Co-Chair
      Kerrie Downing, Kerrie is a transfer student with a very large number of credits. I am her co-chair along with Dr. Zui Pan (Nursing)
    • Present
      Undergraduate Honors Thesis
      Sarah Nelson, (Nursing)
      The effects of glucose on myogenesis
    • Present
      Dissertation Committee Co-Chair
      Jennifer Weber, Co Chair with Drs. Daisha Cipher and Jing Wang. (Nursing)
      Simulation Teaching Approaches
    • Present
      Dissertation Committee Chair
      Logan Moore, (Kinesiology)
      New Models and treatments for Osteoarthritis
    • Present
      Undergraduate Supervised Research
      Sarah Nelson, (Nursing)
      The effects of Glucose on Myogenesis
    • Present
      Dissertation Committee Chair
      Eric Forst, (Nursing)
      Nursing Turover Burden
    • Present
      Dissertation Committee Member
      Kamal Awad, (Material Science and Engineer)
      New Biomaterials for Bone Regeneration
    • Present
      Undergraduate Supervised Research
      Matthew Fieldler, (Kinesiology)
      Dynamic Live Imaging Approaches to Muscle Research
    • Present
      Dissertation Committee Chair
      Donnalee Pollack, Ms. Pollack is also a Jonas Scholar.

      (Nursing)
    • Present
      Dissertation Committee Co-Chair
      Julie Peterson, I am her co-chair along with Dr. Jing Wang (Nursing)
      Cognitive changes in cardiac arrest survivors
    • 2015
      Dissertation Committee Co-Chair
      Sarah Llanque , University of Missouri-Kansas City (Nursing)
      The family series workshop: a community-based psychoeducational intervention
    • 2015
      Dissertation Committee Member
      Ted Rosebaunn, University of Missouri-Kansas City (Nursing)
      Evaluation of Health Outcomes After Cardiac Intervention
    • 2014
      Dissertation Committee Chair
      ChengLin Mo, University of Missouri-Kansas City (Other)
      The Role of PGE2 in Myogenesis
    • 2014
      Dissertation Committee Chair
      Janalee Isaacson, University of Missouri-Kansas City (Nursing)
      Bone-Muscle Crosstalk in Patients with Osteoporotic Fractures
    • 2012
      Dissertation Committee Chair
      Joan Smith, University of Missouri-Kansas City (Nursing)
      The M Technique Massage for Very Pre-Term Babies
    • 2008
      Dissertation Committee Member
      Chris Ferrante, Robert Wood John Medical School/Rutgers (Other)
      Calcium Sparks in Skeletal Muscles
    • Sept 2008
      Dissertation Committee Co-Chair
      Angela Thornton, Department of Physiology & Biophysics, Robert Wood Johnson Medical School Piscataway, NJ
    • 2006
      Dissertation Committee Chair
      Xiaoli Zhao, Graduate of Robert Wood Johnson Medical School/Rutgers (Other)
      Store Operated Calcium Entry and Muscle Fatigue
    • 2003
      Master's Comprehensive Exam Committee Member
      John DiBella, Case Western Medical School (Other)
      A Model of Muscle Metabolism
    • 2003
      Dissertation Committee Member
      Ilma Barros, Case Western Reserve University (Other)
      Models of Organization Behavior

Courses

      • NURS 6399-043 DISSERTATION
        (Course Id: 107601)
        Fall - Regular Academic Session - 2021
      • NURS 6699-001 DISSERTATION
        (Course Id: 107605)
        Fall - Regular Academic Session - 2021
      • NURS 6370-043 INDEPENDENT STUDY IN NURSING
        (Course Id: 107599)
        Fall - Regular Academic Session - 2021
      • KINE 6394-002 RESEARCH IN KINESIOLOGY
        (Course Id: 112822)
        Summer - Eleven Week - 2021
      • NURS 6381-043 RESEARCH PRACTICUM
        (Course Id: 113351)
        Summer - Eleven Week - 2021
      • NURS 6699-043 DISSERTATION
        (Course Id: 107605)
        Spring - Regular Academic Session - 2021
      • NURS 3337-005 INDEPENDENT STUDY
        (Course Id: 107349)
        Spring - Regular Academic Session - 2021
      • NURS 6370-043 INDEPENDENT STUDY IN NURSING
        (Course Id: 107599)
        Spring - Regular Academic Session - 2021
      • NURS 6399-043 DISSERTATION
        (Course Id: 107601)
        Fall - Regular Academic Session - 2020
      • NURS 6370-043 INDEPENDENT STUDY IN NURSING
        (Course Id: 107599)
        Fall - Regular Academic Session - 2020
      • KINE 6106-001 LAB TECHNIQUE ROTATION IN KINE
        (Course Id: 112828)
        Fall - Regular Academic Session - 2020
      • KINE 6194-001 RESEARCH IN KINESIOLOGY
        (Course Id: 112819)
        Fall - Regular Academic Session - 2020
      • NURS 6381-043 RESEARCH PRACTICUM
        (Course Id: 113351)
        Fall - Regular Academic Session - 2020
      • NURS 6381-900 RESEARCH PRACTICUM
        (Course Id: 113351)
        Fall - Regular Academic Session - 2020
      • KINE 6105-001 LAB TECHNIQUE ROTATION IN KINE
        (Course Id: 112827)
        Spring - Regular Academic Session - 2020
      • KINE 4391-001 CONFERENCE COURSE
        (Course Id: 106279)
        Fall - Regular Academic Session - 2019
      • NURS 6370-043 INDEPENDENT STUDY IN NURSING
        (Course Id: 107599)
        Fall - Regular Academic Session - 2019
      • NURS 6370-043 INDEPENDENT STUDY IN NURSING
        (Course Id: 107599)
        Summer - 2019
      • NURS 5315-001 ADVANCED PATHOPHYSIOLOGY
        (Course Id: 107466)
        Spring - Regular Academic Session - 2019
      • NURS 5315-001 ADVANCED PATHOPHYSIOLOGY
        (Course Id: 107466)
        Fall - Regular Academic Session - 2018
      • NURS 6370-043 INDEPENDENT STUDY IN NURSING
        (Course Id: 107599)
        Summer - Eleven Week - 2018
      • NURS 5315-001 ADVANCED PATHOPHYSIOLOGY
        (Course Id: 107466)
        Spring - Regular Academic Session - 2018
      • NURS 6304-001 MEASURE DIVERSE/VULNERABLE
        (Course Id: 107586)
        Spring - Regular Academic Session - 2017
      • NURS 3337-001 INDEPENDENT STUDY
        (Course Id: 107349)
        Fall - Regular Academic Session - 2016

Service to the University

    • May 2003 to  July 2003 Sabbatical Leave
      Department of Physiology & Biophysics (Dr. Jianjie Ma Lab) UMDNJ- RWJMS

Service to the Profession

    • Sept 2020 to  Present
      Editor, Associate Editor (Lausanne , Switzerland)
      Frontiers of Aging - Molecular Mechanisms of Aging
      I am in charge of a team of 15 Review Editors, which I have appointed myself and together we review papers that relevant for the field of Aging with a focus on Musculoskeletal Aging, Disorders, Osteoporosis, and Sarcopenia. I am also to develop topics and help charter the Journal's vision for the next decade.
    • 2019 to  Present
      Editor, Associate Editor
      Current Opinion in Pharmacology, Musculoskeletal Section
    • 2019 to  Present
      Editor, Associate Editor
      Current Osteoporosis Reports, Muscle & Bone Section
    • 2019 to  Present
      Reviewer, Grant Proposal
      National Institutes of Health Fellowships
    • 2018 to  Present
      Reviewer, Grant Proposal
      American Heart Association
    • 2018 to  Present
      International Invited Reviewer
      Health Ministry of the Netherlands
    • 2017 to  Present
      Reviewer, Grant Proposal
      Department of Defense (DoD
    • 2017 to  Present
      International Invited Reviewer
      Health Ministry of Sweden
    • 2017 to  Present
      International Invited Reviewer
      Ministry of Health of Norway
    • 2016 to  Present
      Appointed
      American Heart Association (AHA) National Strategic Committee
    • 2015 to  Present
      Appointed
      American Heart Association (AHA) Southwest Research Committee
    • 2015 to  Present
      Reviewer, Grant Proposal
      Italian Telethon Foundation
    • 2014 to  Present
      Reviewer, Grant Proposal
      Austrian Science Fund
    • 2014 to  Present
      Reviewer, Grant Proposal
      National Institutes of Health Skeletal Muscle and Exercise Physiology Study Section
    • 2014 to  Present
      Permanent NIH Reviewer
      Skeletal Muscle & Exercise Physiology (SMEP) Study Section
    • 2014 to  Present
      Reviewer, Grant Proposal
      Sweden Ministry of Education and Researc
    • 2013 to  Present
      Reviewer, Grant Proposal
      Canada Foundation for Innovation
    • 2012 to  Present
      Editor, Associate Editor
      Journal Letters in Cell Biology
    • 2011 to  Present
      Editor, Associate Editor
      Journal of Bone and Mineral Research
    • 2010 to  Present
      Reviewer, Grant Proposal
      American Federation of Aging Research
    • 2010 to  Present
      Reviewer, Grant Proposal
      University of Missouri Research Board Grants
    • 2009 to  Present
      Reviewer, Ad Hoc Reviewer
      National Institutes of Health
    • 2007 to  Present
      Reviewer, Grant Proposal
      American Heart Association
    • 2006 to  Present
      Editor, Associate Editor
      Journal of Pharmacology & Experimental Therapeutics
    • Past to  2019
      Reviewer, Journal Article
      American Journal of Physiology: Cell
    • Past to  2019
      Reviewer, Journal Article
      American Journal of Physiology: Heart, Lung and Blood
    • Past to  2019
      Reviewer, Journal Article
      American Journal of Physiology: Integrative and Regulatory
    • Past to  2019
      Member
      American Physiological Society
    • Past to  2019
      Reviewer, Journal Article
      Biochemical Pharmacology (France)
    • Past to  2019
      Reviewer, Journal Article
      Biotechnology Progress
    • Past to  2019
      Reviewer, Journal Article
      Brain Research Bulletin
    • Past to  2019
      Reviewer, Journal Article
      Cell Calcium
    • Past to  2019
      Editorial Review Board Member
      Dialogos em Ciencia (Brazil)
    • Past to  2019
      Reviewer, Journal Article
      Journal of Applied Physiology
    • Past to  2019
      Reviewer, Journal Article
      Journal of Biological Chemistry
    • Past to  2019
      Editorial Review Board Member
      Journal of Bone and Mineral Research (JBMR)
    • Past to  2019
      Reviewer, Journal Article
      Journal of Gerontology
    • Past to  2019
      Editorial Review Board Member
      Journal of Open Letters in Biology
    • Past to  2019
      Editorial Review Board Member
      Journal of Open Letters in Cell Biology
    • Past to  2019
      Reviewer, Journal Article
      Journal of Pharmacology and Experimental Therapeutics
    • Past to  2019
      Editorial Review Board Member
      Journal of Pharmacology and Experimental Therapeutics (JPET)
    • Past to  2019
      Reviewer, Journal Article
      Journal of Physiology (London)
    • Past to  2019
      Reviewer, Journal Article
      Muscle & Nerve
    • Past to  2019
      Reviewer, Journal Article
      Physiological Genomics
    • Past to  2019
      Reviewer, Journal Article
      Recent Patents on Biotechnology
    • Past to  2019
      Reviewer, Journal Article
      Rejuvenation Research
    • 2014 to  2015
      Officer, President/Elect/Past
      Missouri Physiological Society
    • Past to  2010
      Director of the Biomedical Research Center (Salvador, Brazil ,
      College of Sciences & Technology
    • Past to  June 2008
      Organizer and Chair
      1st Muscle Biology Symposium at UMKC
    • Past to  2006
      Moderator
      Robert Wood Johnson Medical School Summer Fellowship Presentations
    • Past to  Apr 2000
      Organizer and Chairperson (San Diego, California,
      Experimental Biology (EB 2000) Symposium: Hypoxia-Induced Muscle Damage from Reactive Oxygen Intermediates: From Pathways to Function