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Woo-Suk Chang

Name

[Chang, Woo-Suk]
  • Associate Professor

Biography

· Ph.D.  May 2005 Department of Microbiology, Iowa State University.

· M.S.   Feb. 1998 Department of Biological Engineering, Inha University.

· B.E.   Feb.  1996 Department of Biological Engineering, Inha University.

Professional Preparation

    • 2005 Ph.D. in MicrobiologyIowa State University

Appointments

    • May 2014 to Present Associate Professor
      University of Texas at Arlngton
    • Aug 2008 to May 2014 Assistant Professor
      University of Texas Arlington
    • May 2005 to July 2008 Post-doctoral Associate
      University of Missouri-Columbia

Memberships

  • Membership
    • Jan 2013 to Present Internaitonal Society for Molecular Plant-Microbe Interactions
    • Jan 2008 to Present The Korean Society for Microbiology and Biotechnology
    • Jan 2000 to Present American Society for Microbiology

Awards and Honors

    • Dec  2011 Outstanding Service sponsored by American Society for Microbiology
      Description:

      Outstanding service as an online mentor of the ASM minority mentoring program in 2011

News Articles

    • July 2013 IS-MPMI Reporter

      International Society for Molecular Plant-Microbe Interactions (IS-MPMI) Reporter issue No. 2, July 2013. "Member Spotlight" highlighting the recent successes of MPMI colleagues inclduing Chang's Laboratory.

Research and Expertise

  • Woo-Suk Chang's Research Interests

    Dr. Chang is a microbiologist interested in microbial genomics, plant-microbe interactions, and virus infection. Specifically his interests are in symbiotic interaction between rhizobia and legume plants, bioenergy, greenhouse gas emissions, microbial biofilms, and recenlty influenza infection.

    1. The soil bacterium Bradyrhizobium japonicum is an agriculturally important microorganism as it is the microsymbiont of soybean, the second most valuable crop plant in the U.S. behind corn. In addition to the use in food industry, soybean accounts for 80% of biodiesel production in the U.S. Clearly, there has been an increase in demand for more soybean production. Although there are several practical approaches to achieving increased production and crop yields, ranging from optimization of the use of chemical nitrogen fertilizers to development of genetically engineered herbicide-tolerant and/or insect-resistant soybeans, little is focused on fundamental improvement of nitrogen fixation by B. japonicum whose culture has been applied as inoculants (i.e., biological fertilizers) to the field. To improve inoculant performance and optimize the benefits of biological nitrogen fixation, it is important to fully understand how B. japonicum responds to alterations in the soybean root environment (rhizosphere). The objective of this project is to reveal global gene expression and relevent metabolites of B. japonicum that responds physiologically and metabolically to chemical cues released into the soybean rhizosphere by the plants using functional genomics such as RNA-seq and metabolomics. Dr. Chang is also going to employ a culture-independent metagenomic and metatranscriptomic approaches to increase our understanding of how rhizobial communities, rather than a species, interact with legume plants.

    2. Microbial biofilm (specifically unsaturated biofilm) in several Pseudomonas strains is the other area of interest. Infection of medical devices is caused by formation of bacterial biofilms on the surface of the device. Biofilms on medical devices are the source of major challenges for medical settings because bacteria within biofilms are a lot more resistant to antibiotics compared to the free floating or planktonic bacteria. In general, the best way of fighting with biofilms is early detection and prevention of biofilm formation in the first place, which requires sensitive sensors. Therefore, in collaboration with UT-Dallas (Dr. Minary) and UNTHSC (Dr. Simecka), there is a pressing need for development of sensors that can sense the biofilm formation in very early stages. In addition, Dr. Chang has tried to understand how the molecular mechanism is involved in unsaturated biofilm formation and development.

Publications

      Journal Article 2015
      • Chung, E. J., T. S. Park, K. H. Kim, C. O. Jeon, H.-I Lee, W.-S. Chang, Z. Aslam, and Y. R. Chung (2015) Nitrospirillum irinus sp. nov., a diazotrophic bacterium isolated from the rhizosphere soil of Iris and emended description of the genus Nitrospirillum. Antonie van Leeuwenhoek 108:721-729

        {Journal Article} [Refereed/Juried]
      2015
      • Thaweethawakorn, A., D. Parks, J.-S. So, and W.-S. Chang* (2015) Role of the extracytoplasmic function sigma factor CarQ in oxidative response of Bradyrhizobium japonicum. J. Microbiol. 53:526-534

        {Journal Article} [Refereed/Juried]
      2015
      • Taw, M. N., H.-I. Lee, S.-H. Lee, and W.-S. Chang* (2015) Characterization of MocR, a GntR-like transcriptional regulator, in Bradyrhizobium japonicum: its impact on motility, biofilm formation, and soybean nodulation. J. Microbiol. 53:518-525

        {Journal Article} [Refereed/Juried]
      2015
      • Jeon, J.-M., H.-I. Lee, M. J. Sadowsky, M. Sugawara, and W.-S. Chang* (2015) Characterization of a Functional Role of the Bradyrhizobium japonicum isocitrate lyase in desiccation tolerance. Int. J. Mol. Sci. 16:16695-16709

        {Journal Article} [Refereed/Juried]
      2015
      • Noh, J.-G., H.-E. Jeon, J.-S. So, and W.-S. Chang* (2015) Effects of the Bradyrhizobium japonicum waaL (rfaL) gene on hydrophobicity, motility, stress tolerance, and symbiotic relationship with soybeans. Int. J. Mol. Sci. 16:16778-16791

        {Journal Article} [Refereed/Juried]
      2015
      • Franck, W. L., J. Qiu, H.-I. Lee, W.-S. Chang*, and G. Stacey (2015) DNA microarray-based identification of genes regulated by NtrC in Bradyrhizobium japonicum. Appl. Environ. Microbiol. 81:5299-5308

        {Journal Article} [Refereed/Juried]

      Journal Article 2014
      • Lee, H.-I., Y.-H. In, S.-Y. Jeong, J.-M. Jeon, J. G. Noh, J.-S. So, and W.-S. Chang* (2014) Inactivation of the lpcC gene alters surface-related properties and symbiotic capability of Bradyrhizobium japonicum. Lett. Appl. Microbiol. 59: 9-16

        {Journal Article} [Refereed/Juried]
      2014
      • Kim, G-P., Lee, J., Ahn, K-G., Hwang, Y-S., Choi, Y., Chun, J., Chang, W.-S., Choung, M-G. (2014) Differential responses of B vitamins in black soybean seeds. Food Chem. 153: 101-108

        {Journal Article} [Refereed/Juried]
      2014
      • Silipo, A., G. Vitiello, D. Gully, L. Sturiale, C. Chaintreuil, J. Fardoux, D. Gargani, H.-I. Lee, R. Marchetti, A. Palmigiano, D. Garozzo, H. Moll, R. Engel, W.-S. Chang, O. Holst, R. Lanzetta, L. Paduano, M. Parrilli, G. D’Errico, E. Giraud, A. Molinaro (2014) Hopanoid-lipid A, a new component improving bacterial membrane resistance. Nature Communications 5: 5106

        {Journal Article} [Refereed/Juried]
      2014
      • Frank, S., W. L. Frank, S. R. Birke, W.-S. Chang, D. P. Sangurdekar, E. Cytryn, T. Joshi, M. Sadowsky, G. Stacey, D. Xu, and D. W. Emerich (2014) Comparative transcriptomic analysis of symbiotic Bradyrhizobium japonicum. Symbiosis 63:123-135

        {Journal Article} [Refereed/Juried]

      Journal Article 2013
      • Lee, J., Y.-S. Hwang, W.-S. Chang, J.-K. Moon, and M.-G. Choung (2013) Seed maturity differentially mediates metabolic responses in black soybean. Food Chem. 141: 2052-2059.

        {Journal Article} [Refereed/Juried]
      2013
      • Lee, J., Y.-S. Hwang, J.-D. Lee, W.-S. Chang, and M.-G. Choung (2013) Metabolic alterations of lutein, b-carotene and chlorophyll a during germination of two soybean sprout varieties. Food Chem. 141: 3177-3182.

        {Journal Article} [Refereed/Juried]
      2013
      • Anton, B. P., Y.-C. Chang, P. Brown, H.-P. Choi, L. L. Faller et al. W.-S. Chang (total 72 co-authors) (2013) The COMBREX Project: Design, methodology, and initial results. PLoS Biol. 11(8): e1001638.

        {Journal Article} [Refereed/Juried]
      2013
      • Donati, A. J., H.-I Lee, J. H. J. Leveau, and W.-S. Chang* (2013) Effects of indole-3-acetic acid on the transcriptional activities and stress tolerance of Bradyrhizobium japonicumPLoS One 8(10): e76559.

        {Journal Article} [Refereed/Juried]
      2013
      • Lee, H.-I., A. J. Donati, D. Hahn, L. S. Tisa, and W.-S. Chang* (2013) Alteration of the exopolysaccharide production and the transcriptional profile of free-living Frankia strain CcI3 under nitrogen-fixing conditions. Appl. Microbiol. Biotechnol. 97: 10499-10509

        {Journal Article} [Refereed/Juried]

      Journal Article 2012
      • Cheong, D.-E., W.-S. Chang, and G.-J. Kim (2012) A cloning vector employing a versatile b-glucosidase as an indicator for recombinant clones. Anal. Biochem. 425: 166-168.

        {Journal Article} [Refereed/Juried]
      2012
      • Lee, H.-I., J.-H. Lee, K.-H. park, D. Sangurdekar,and W.-S. Chang* (2012) Effect of soybean coumestrol on nodulation, biofilm formation, and the transcriptional profile of Bradyrhizobium japonicum. Appl. Environ. Microbiol. 78: 2896-1903.
        {Journal Article} [Refereed/Juried]
      2012
      • Song, L-S., Y.-H. Kim, S.-J. Lee, Y.-S. Hwang, C.-H. Kwon, J.-A. Do, J.-H. Oh, M. H. Im, W.-S. Chang, Y. D. Lee, and M.-G. Choung (2012) Determination of cyromazine residues in agricultural commodities using HPLC-UVD/MS. Korean J. Pest. Sci. (Abstract written in English, but the article written in Korean). 16: 202-208.

        {Journal Article} [Refereed/Juried]

      Journal Article 2011
      • Park, S.-Y., J.-Y. Lee, W.-S. Chang, H. E. Choy, and G.-J. Kim. (2011) A coupling process for improving purity of bacterial minicells by holing/lysine. J. Microbiol. Methods. 86: 108-110.

        {Journal Article} [Refereed/Juried]
      2011
      • Andrew, J. Donati, J.-M. Jeon, D. Sangurdekar, J.-S. So, and W.-S. Chang. (2011) The Genome-Wide Transcriptional and Physiological Responses of Bradyrhizobium japonicum to Paraquat-Mediated Oxidative Stress. Appl. Environ. Microbiol. 77: 3633-3643

        {Journal Article} [Refereed/Juried]
      2011
      • Silipo, A., M. R. Leone, G. Erbs, R. Lanzetta, M. Parrilli, W.-S. Chang, M-A. Newman, and A. Molinaro. (2011) A unique bicyclic monosaccharide from the Bradyrhizobium lipopolysaccharide and its role in the molecular interaction with plants. Angew. Chem. Int. Ed. 50: 12610-12612.

        {Journal Article} [Refereed/Juried]
      2011
      • Jeon, J.-M., H.-I. Lee, A. J. Donati, J.-S. So, D. W. Emerich, and W.-S. Chang. (2011) Whole-genome expression profiling of Bradyrhizobium japonicum in response to hydrogen peroxide. Mol. Plant-Microbe Interact. 24: 1472-1481.

        {Journal Article} [Refereed/Juried]

      Journal Article 2010
      • Kim, K. P.; Kim, C. H. C.; Kim, J. Y. Y.; Chang, W. S.; Lee, C. S. In situ monitoring of antibiotic susceptibility of bacterial biofilms in a microfluidic device. Lab on a Chip 2010, 26, 351-356.

        {Journal Article} [Refereed/Juried]
      2010
      • Jeong, H. H.; Lee, J. M. K.; Kim, Y. G. K.; Yoo, W. S. C.; Lee, C. S. Microfluidic monitoring of Pseudomonas aeruginosa chemotaxis under the continuous chemical gradient. Biosens. Bioelectron. 2010, 10, 3296-3299.
        {Journal Article} [Refereed/Juried]
      2010
      • Lee, Y. W.; Jeong, Y. H. I.; Kim, J. S. S.; Chang, W. S. Lack of O-polysaccharide enhances biofilm formation by Bradyrhizobium japonicum. Lett. Appl. Microbiol. 2010, 50, 452-456.
        {Journal Article} [Refereed/Juried]

      Journal Article 2009
      • Chang, W. S.; Li, X.; Halverson, L. J. Reduced water availability influences endogenous oxidative stress and cell death within unsaturated Pseudomonas putida biofilms. Environ. Microbiol. 2009, 11, 1482-1492.
        {Journal Article} [Refereed/Juried]

      Journal Article 2008
      • Franck, W. L.; Chang, J. Q.; Sugawara, M. J. S.; Smith, S. A.; Stacey, G. Whole-genome transcriptional profiling of Bradyrhizobium japonicum during chemoautotrophic growth. J. Bacteriol. 2008, 190, 6697-6705.
        {Journal Article} [Refereed/Juried]
      2008
      • Chang, W. S.; Park, S. C. K.; So, J. S. Characterization of the Bradyrhizobium japonicum galE gene: its impact on lipopolysaccharide profile and nodulation of soybean. FEMS Microbiol. Lett. 2008, 280, 242-249.
        {Journal Article} [Refereed/Juried]

      Journal Article 2007
      • Chang, W. S.; de Mortel, L. N.; de Guzman, X. L.; Halverson, L. J. Alginate production by Pseudomonas putida creates a hydrated microenvironment and contributes to biofilm architecture and stress tolerance under water-limiting conditions. J. Bacteriol. 2007, 189, 8290-8299.
        {Journal Article} [Refereed/Juried]
      2007
      • Chang, W. S.; Franck, E. C.; Jeong, T. J.; Emerich, M. J. S.; Xu, D.; Stacey, G. An oligonucleotide microarray resource for transcriptional profiling of Bradyrhizobium japonicum. Mol. Plant-Microbe Interact. 2007, 20, 1298-1309.
        {Journal Article} [Refereed/Juried]
      2007
      • Cytryn, E. J.; Sangurdekar, J. G. S.; Franck, W. S. C.; Stacey, D. W. E.; Joshi, D. X.; Sadowsky, M. J. Transcriptional and physiological responses of Bradyrhizobium japonicum to desiccation-induced stress. J. Bacteriol. 2007, 189, 6751-6762.
        {Journal Article} [Refereed/Juried]
      2007
      • Giraud, E.; Moulin, D. V., V; Barbe, E. C.; Avarre, M. J.; Simon, F. C.; Prin, G. B.; Hannibal, J. F.; Kojadinovic, L. V.; Lajus, S. C.; Rouy, S. M.; Segurens, C. D. Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia. Science 2007, 316, 1307-1312.
        {Journal Article} [Refereed/Juried]

Courses

      • BIOL 3445-001 METHODS IN MOLECULAR MICROBIOLOGY

        This course is intended to provide students with an overview of different techniques used during manipulation of microorganisms. It will allow students to gain a historical perspective of techniques used in microbiology (e.g., Winogradsky column) as well as learn state of the art molecular characterization of microorganisms and their genetic manipulation.

        Fall - Regular Academic Session - 2015 Download Syllabus Contact info & Office Hours
      • BIOL 5421-001 Methods in Molecular Microbiology

        This course is intended to provide students with an overview of different techniques used during manipulation of microorganisms. It will allow students to gain a historical perspective of techniques used in microbiology (e.g., Winogradsky column) as well as learn state of the art molecular characterization of microorganisms and their genetic manipulation.

        Fall - Regular Academic Session - 2015 Download Syllabus Contact info & Office Hours
      • BIOL 3444-001 GENERAL MICROBIOLOGY
        Fundamental principles of microbiology including the structure and function of microbial cells and their activities in nature.
        Spring - Regular Academic Session - 2013 Download Syllabus
      • BIOL 4302-001 MICROBIAL GENETICS
        Consideration of the nature, expression and regulation of the genetic processes in microorganisms.
        Fall - Regular Academic Session - 2012 Download Syllabus
      • BIOL 3444-001 GENERAL MICROBIOLOGY
        Fundamental principles of microbiology including the structure and function of microbial cells and their activities in nature.
        Spring - Regular Academic Session - 2012 Download Syllabus
      • BIOL 4302-001 MICROBIAL GENETICS
        No Description Provided.
        Fall - Regular Academic Session - 2011 Download Syllabus
      • BIOL 3444-001 GENERAL MICROBIOLOGY
        Fundamental principles of microbiology including the structure and function of microbial cells and their activities in nature.
        Spring - Regular Academic Session - 2011 Download Syllabus
      • BIOL 4302-001 MICROBIAL GENETICS
        Consideration of the nature, expression and regulation of the genetic processes in microorganisms.
        Fall - Regular Academic Session - 2010 Download Syllabus
      • BIOL 3444-001 GENERAL MICROBIOLOGY
        Fundamental principles of microbiology including the structure and function of microbial cells and their activities in nature.
        Spring - Regular Academic Session - 2010 Download Syllabus
      • BIOL 3444-001 GENERAL MICROBIOLOGY
        Fundamental principles of microbiology including the structure and function of microbial cells and their activities in nature.
        Fall - Regular Academic Session - 2009 Download Syllabus

Service to the Community

  • Volunteered
    • 2012 to  Present Rhizobium project

      "Rhizobium project" to study how efficiently rhizobial strains can be applied as an inoculant in soils and rhizospheres. This project has been conducted with Fort Towson High School students Lane Johnson, Trenton Cadle, Brody Pettyjohn, Amy Burkhalter, and Mecaela Church and Teacher Niccole Rech and Dr. James Heitholt at Texas A&M-Comerce.

Service to the Profession

  • Appointed
    • May 2013 to  Present Organizer

      The 2013 International Meeting of the Microbiological Society of Korea (MSK), Republic of Korea, May 2013

    • May 2013 to  Present Convener

      The Nobel Lecture by Dr. Robert Huber, a Nobel Prize Awardee in Chemistry in 1988. Translation of his lecture, questions and answers to the audience, Republic of Korea, May 2013.

    • 2011 to  Present Mentor

      Serve as a mentor of the ASM minority mentoring program

    • Nov 2011 to  Nov 2011 Organizer

      The 43rd Annual Fall Meeting of the Texas Branch American Society for Microbiology (ASM). UTA, TX. Nov. 2011

    • 2010 to  Present Underrepresented members committee

      The membership board and the underrepresented members committee of ASM

  • Elected
    • Jan 2014 to  Present Editor

      Journal of Microbiology

    • 2013 to  Present Advisory Committee

      The 22th North American Conderence on Symbiotic Nitrogen Fixation (NACSNF), University of Minnesota

    • Jan 2013 to  Present Editorial Board

      Applied and Environmental Microbiology

    • 2012 to  Present Future Development Advisory Committee

      The Microbioogical Society of Korea (MSK)

  • Volunteered
    • 2011 to  Present Judge

      Presentation judge, International Symposium of the Korean Society for Microbiology and Biotechnology (KSMB), Republic of Korea

    • 2008 to  Present Judge

      Presentation judge, The Texas & South Central Branch Annual ASM meeting, Austin, TX

Service to the University

  • Appointed
    • 2009 to  Present EES

      Environmental and Earth Science (EES) graduate studies committee.

    • Aug 2013 to  Present GSAC

      Graduate Student Advisory Committee (GSAC) in Biology Department 

  • Volunteered
    • 2013 to  2013 Judge

      Oral presentation judge, Annual Celebration of Excellence by Students (ACES), UTA

    • 2013 to  Present REP

      Research Enhancement Program (REP) review committee

    • 2012 to  2012 Advisor

      I ENGAGE program student, Dylan Parks

    • 2011 to  Present Diagnostic Exam Subcommittee

      GSAC subcommittee for preparing diagnostic exams

    • 2011 to  2011 Comprehensive Exam Subcommittee

      GSAC subcommittee for reviewing comprehensive exams

    • 2009 to  Present Mentor

      Honors student project, several students (currenlty, Vivian Nguyen), Honors College

    • 2008 to  Present Advertising

      Advertisement of UTA graduate school to more than 17 foreign institutions. This also includes introduction of UTA and benefit of studying abroad at UTA. This activity has been supported by UTA graduate school.

    • 2008 to  2010 Organizer

      Microbiology Journal Club