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Jun 2018 - Jan 2024
AEDC 16T Wind Tunnel Compressor Blades - Technical Consultation and Engineering Review sponsored by Innovation, Integration, Inc. (i3)
Innovation, Integration, Inc.
(i3) is contracted by the Government to support the Arnold Engineering and Development Complex (AEDC) in the development and manufacturing of blades for the compressor powering the 16T Wind Tunnel. The proposal development and the execution of the two-phased project require ongoing support through engineering services and expertise. The University of Texas at Arlington will provide Technical Consultaion and Engineering Review support to i3 on an as necessary/requested basis, with an initial estimated effort level of 0.5 months of PI time, in the technical expertise areas of the PI and, if and when necessary, of additional UT Arlington complementary subject matter experts whose additional effort and contribution will be included in a co-PI capacity, if/when necessary. i3 anticipates requiring technical consultation and engineering review in the areas of: Engineering material selection, comparison, and characterization Mechanical testing and evaluation of subassemblies and assembly methodologies Independent review of analysis results for thoroughness and validity Consultation and recommendations for engineering best practices in the areas of composite rotorcraft components Consultation and recommendations for engineering best practices in the areas of additive manufacturingread more...
Sep 2018 - Aug 2023
Louis Stokes STEM Pathways and Research Alliance: University of Texas System LSAMP sponsored by University of Texas at El Paso
Objective: The primary goal the project is to increase the quantity and quality of underrepresented minority (URM) students that pursue and earn degrees in Science, Engineering, Technology, and Mathematics (STEM) in the state of Texas and the nation.
In addition, it promotes undergraduate degree completion, early planning for graduate studies and making the professoriate an attainable career goal among our scholars. These activities outlined for the program are centered on a set of interconnected undergraduate research experiences, designed to advance knowledge and understanding of the academic factors that enable URM students to successfully earn STEM degrees, pursue graduate degrees and successful transition to their careers. Scope: Published evidence has consistently identified undergraduate research as a high impact educational practice that improves retention and progression rates through the entire academic career, aids in career planning, and increases interest in pursuing graduate degrees. In this project, UTA will identify pair selected students with faculty mentors students who will oversee the students’ participation an intensive undergraduate research experience via the Summer Research Academy (SRA) that may lead to a research abroad experience. Background: Since 1995, UTA has been a proud partner and collaborator of the UT System LSAMP and has dedicated resources to the education of a diverse STEM workforce in the United States. High-impact research is one of the guiding aspirations for the University’s strategic plan, and UTA is committed to increasing student engagement in these types of transformative experiences that provide unique learning opportunities to enhance the educational, career, and life skills of UTA students. Tasks/Scientific Goals: Ms. Alisa Johnson will serve as the campus co-Director and will manage the campus activities supported by the grant. Each year, UTA will encourage students to participate in a ‘university exchange’ and will host four students in the Summer Research Academy. These undergraduate STEM majors will work on an active research project at a UT System institution under the direction of dedicated faculty mentors. In addition to providing a venue for students to participate in of professional development teleconferences, UTA will provide a series of professional development seminars on topics such as career development, presenting their research, and preparing for graduate school. This programming will include a boot camp designed to help students apply for NSF Graduate Research Fellowship Program and other prestigious awards. This program allows students to engage in what can be a life-changing experience that helps them to redefine their career goals to include master’s and doctoral studies, and develop professional skills for success. Each student participant will also be encouraged to participate in the international student international research experience that alumni from this program may apply to pursue. In addition to the conferences that focus on professional development and graduate school preparation, students will be provided opportunities for students to attend professional conferences and meetings in their respective fields to present their research. UTA will evaluate the research experience with pre and post experience surveys, as well as presentation sand writing samples of participants. Results of this effort will be disseminated broadly through journal and conference publications as well as regional and national presentations.read more...
Jul 2018 - Jun 2023
Loss of Numb in Muscle Dysfunction in Aging sponsored by Bronx Veterans Medical Research Foundation, Inc.
Drs. Brotto and Cardozo have now a very solid collaboration having generated together the preliminary data for this proposal and having presented at meetings and published one abstract together.
Their first manuscript together will be published soon. Dr. Brotto will closely work with Dr. Cardozo in all the design, planning, and interpretation of all experiments requiring his expertise, particularly muscle and cell based experiments requiring his expertise. He will also advise Dr. Cardozo on other aspects of the proposal as needed and assist with interpretation of data and writing of manuscripts. They also plan to meet yearly at the ASBMR meeting and potentially one more time either through Lab visits or at the Experimental Biology or Biophysical Meeting.read more...
Jun 2018 - May 2023
Preparing Highly Qualified STEM Teachers in High Need Schools through the NSF Robert Noyce Program sponsored by National Science Foundation (NSF)
This proposed new project: Preparing Highly Qualified STEM Teachers in High Need Schools through the NSF Robert Noyce Program, will build upon our successful Noyce program at The University of Texas at Arlington (UTA) in collaboration with our partner school districts and community college district.
Our program has established a strong and on-going pipeline of new secondary science and mathematics teachers who are in high demand by surrounding schools. The new project will leverage lessons learned from our prior successes and challenges while meeting the critical need to offer Noyce Scholarships to recruit, prepare, induct, and retain STEM teachers for our high-need schools. The program aims to extend the collaborative work among the UTA College of Education (COEd) and College of Science (COS), Tarrant County Community College District (TCCD), and the surrounding Dallas, Arlington, and Fort Worth Independent School Districts to prepare and certify new science and mathematics teachers highly qualified to teach in these high-need, urban districts. In addition, this project will also recruit Engineering candidates into a new computer science/mathematics teacher certification track within their baccalaureate degree. This project therefore extends our collaborative work to include the College of Engineering (COE), such that in addition to recruiting and supporting secondary science and mathematics teacher candidates through Noyce Scholarships, we will also target engineering students seeking computer science/mathematics certification. Specific program objectives are to: recruit mathematics, science, and computer science teacher candidates from community colleges, baccalaureate programs, and career changers from local industry, provide a quality teacher certification program for candidates with significant faculty mentoring, support, and professional development experiences streamed throughout the program, and support and promote teacher induction and retention in the profession, implementing various levels of guidance from professional educators, school-based Mentor Teachers, and Near-Peer Mentors. This proposed Noyce project aims to prepare 50 new, highly qualified teachers in the high need areas of science, mathematics, and computer science and provide summer internships to 40 STEM freshman and sophomore as a strategy for teacher candidate recruitment.read more...
May 2018 - Apr 2023
Veterans Business Outreach Center (VBOC) sponsored by Small Business Administration
Funding Opportunity Number – Title: VBOC-2018-01b – Veteran Business Outreach Centers (VBOC) UTAVBOC will provide information on small business ownership to service members and military spouses by facilitating and instructing the U.
S. Small Business Administration’s “Introduction to Entrepreneurship” known as “Boots to Business” which is a course offered within the Department of Defense Transition Assistance Program (TAP). Additionally, UTAVBOC will provide counseling, training, technical and financial skill development, comprehensive business assessments and mentoring to veteran, service disabled veteran, active duty, Reserve, Guard, and military spouse/survivor entrepreneurs and small business owners interested in starting new or expanding/diversifying established small businesses. This Program Announcement is subject to the availability of funding. Vision The Veterans Business Outreach Center at the University of Texas Arlington (UTAVBOC) is the premier resource for education, training and inspiration to empower transitioning veterans, disabled veterans, National Guard, active and reserve component members, and their spouses to become business owners. Mission UTAVBOC provides collaborative, hands-on, interactive learning opportunities for transitioning veterans, disabled veterans, National Guard and reserve component members, and spouses through a community of entrepreneur resource partners nationally, locally and across US Small Business Administration Region VI. Through ongoing one-on-one business counseling, training programs, accredited university courses, practical seminars, workshops and referrals, UTAVBOC represents the SBA for transitioning veterans in North Texas, Oklahoma, and Arkansas. UTAVBOC services are funded in part through a cooperative agreement with the US Small Business Administration (SBA) in appreciation for the veterans’ valued and continued service to the nation in order to grow the US economy and the employment base while adding value to the veterans and the communities in which they live. UTAVBOC’s mission is to 1. Increase veteran awareness of entrepreneurial development services through the Boots to Business entrepreneurial education and training programs. 2. Increase veteran access to entrepreneurial development services in collaboration with other SBA resource partners.read more...
Apr 2018 - Apr 2023
City of Adidis Abada and Kotebeo Metropolitan Metropolitan University sponsored by Kotebe Metropolitan University
To establish a special scholarship program between The University ofTexas at Arlington ("UTA") and The Kotebe Metropolitan University (KMU) that would assure a well -defined process for select high-achieving students through programs that begin with ·selection andadmission of students and continues through graduation.
The program is structured to assure studentsuccess through special focus on mentoring, interactions, and a focus on research with the CivilEngineering (CE) at the Co.llege of Engineering.KMU I the City Government of Addis Ababa agree to send between 5 (five) to 10 (ten) fully fundedMS/Ph.D. students per year to enroll at UTA to utilize UTA's expertise to educate and train the stu·dents•· . (personnel) from both City Government of Addis Ababa and KMU. KMU /the City Government of AddisAbaba will also send Postdoctoral Fellows instead of MS students, as determined by KMU. The first groupof students is expected to enroll and start in the Spring 2019 semester. The following are the major focusareas for education and training:• Sustainable Solid Waste Management• Urban Environmental' Engineering• Urban Management and Leadership• Resilient and Smart City• Civil I Architectural I Sanitation I Roadway Engineering• Other Emerging Areas, as need basis.UTA's Solid Waste Institute for Sustainability (SWIS) will be the facilitator between UTA and KMU, as theCity of Addis Ababa is a Chartered.Member of SWIS. SWIS will co-ordinate the program between UTAand KMU.read more...
Apr 2018 - Mar 2023
Estrogen and Zoster Associated Orofacial Pain sponsored by Texas A&M University System (TAMU)
Pain is a common complication of herpes zoster (HZ) infection which results from reactivation of a latent varicella zoster virus (VZV).
Importantly, about 80% of trigeminal ganglia are infected with VZV and womenreport pain due to HZ up to 3 times more often than men but the reason for sex this difference is unknown. To address the mechanism for this sex difference a screen of over 30,000 genes in five brain regionsindicated that glutamate decarboxylase 2 GAD2, and vesicular GABA transporter (VGAT) were elevated in the thalamus of proestrus, high 17 ?-estradiol (E2) versus diestrus rats (low E2). Using a rat model fororofacial VZV associated hypersensitivity ovariectomized (OVX) female rats had greater VZV associated hypersensitivity than male rats and blockade of E2 production in males by aromatase antagonist letrozoleincreased VZV associated hypersensitivity. Moreover, reducing VGAT in the thalamus increased hypersensitivity. Based on these preliminary studies it was hypothesized that E2 reduces orofacial zosterassociated hypersensitivity through increasing VGAT or GAD2 expression. To test this we propose the following three specific aims. Aim #1 will characterize thalamic inhibitory pathways that control VZVassociated orofacial hypersensitivity. Our working hypothesis is that GABA expressing inter-neurons in the reticular thalamic nuclei (Rt) or zona incerta (ZI) inhibit activity in the posterior thalamic nuclei (Po) orventroposteriormedial thalamic nucleus (VPM) to reduce VZV associated orofacial hypersensitivity. To test this hypothesis first, VZV associated hypersensitivity and neuronal activity in the Po and VPM will bemeasured after inhibiting or stimulating these interneurons. Second, hypersensitivity and activity will be determined after modulating VGAT and GAD2 expression in these interneurons. Aim #2 will determine therole of sex steroids on VZV associated orofacial hypersensitivity and cellular activity in both males and females. Our working hypothesis is that elevated E2 increases expression of VGAT and GAD2 in thethalamus to modulate neuronal activity and reduce VZV associated hypersensitivity in both female and male rats. Hypersensitivity and neuronal activity will be measured after E2 is administered to OVX rats and after E2 and aromatase inhibitors are administered to male rats. Aim #3 will characterize the mechanism by which sex steroids modulate VGAT and GAD2 expression in the lateral thalamic region of males and females. Our working hypothesis is that E2 binds estrogen receptor (ER?) to increase expression of VGAT and GAD2 in the lateral thalamus. We expect to show 1) that GABA inter-neurons of the ZI or Rt inhibit orofacial pain responses, 2) that elevated E2 increases VGAT and GAD2 in males and females through a ER? dependent mechanism and 3) that these genes are responsible, in part, for the decrease in hypersensitivity observed in males. Upon completion of these studies a novel mechanism by which E2 affects orofacial hypersensitivity will be identified providing new targets for treating people suffering from HZ associated pain.read more...
Jan 2018 - Feb 2023
Physics-Based Composite Process Simulation sponsored by Office of Naval Research (ONR)
The University of Texas at Arlington and Bell Helicopter Textron are teaming in the proposed effort to develop Physics-Based Composite Process Simulation Abilities.
The objective of this effort is to develop a cure process model for predicting curing behaviors of composite laminates. The subject model will predict the processing window and laminate quality using variables such as material form and placement technique, part layup scheme, tool geometry, cure equipment and cure cycle, in which defects such as porosity and fiber waviness are less favored to form in the final cured part. The underlying physical principles of the model are critical in understanding the science behind the formation of such defects during processing. The proposed effort will result in a high-fidelity, physically accurate and validated cure process model accelerating the development of robust and efficient composite manufacturing processes that improves part quality and shortens cycle time.read more...
Feb 2018 - Jan 2023
Mechanism and Modulation of Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction sponsored by National Institutes of Health (NIH)
Obesity has reached epidemic proportions world-wide, and has led to a parallel rise in the prevalence of type 2 diabetes mellitus (T2D), together with an associated risk of cardiovascular disease and death.
The risk for heart failure in obesity is greater than can be accounted for by traditional risk factors such as hypertension and coronary artery disease. Altered substrate metabolism is thought to contribute importantly to dysfunction of the obese and diabetic heart; however, the exact mechanism leading to dysfunction remains incompletely understood. One increasingly popular theory involves lipid overstorage (termed steatosis) and lipotoxic injury to cardiomyocytes. These data have been derived almost entirely using pre-clinical rodent models however, with translational human research being far less developed. Attempts to translate this work to human subjects have been limited to correlations in patient groups with various underlying co-morbidities. To address this major limitation, we propose a novel and innovative food restriction model, which reproducibly causes a transient, physiological increase in myocardial triglyceride content in young healthy individuals. This experimental approach will provide the most controlled environment to test if myocardial steatosis is directly related to cardiac dysfunction—independent of underlying co-morbidities. Our preliminary data suggest that when exposed to acute lipid overstorage, men—but not premenopausal women— develop LV diastolic dysfunction. Based on this observation we will: 1) Test the hypothesis that cardiac steatosis induced left ventricular dysfunction is sexually dimorphic, by comparing age-matched men and premenopausal women before and after an acute fasting intervention. 2) Test the hypothesis that estrogen is protective against cardiac steatosis-induced dysfunction, by suppressing ovarian sex hormones with a GnRH antagonist and repeating the fasting studies with and without estrogen add-back. 3) Test whether plasma and myocardial fatty acid composition is sexually dimorphic, by performing comprehensive plasma and myocardial lipidomics assessment. The results will provide new and important mechanistic insight into the independent role of myocardial steatosis and its influence on cardiac function in otherwise healthy young human subjects. The results also promise to address the NIH mandate focusing on the influence of sex on disease risk. Taken together, these novel and innovative studies will facilitate paradigm-changing diagnosis and treatment approaches to reduce the burden of heart disease in obesity and diabetes.read more...